Diagnostic tests and prognostic indicators

New patterns of relapse in multiple myeloma: a case of “light chain escape” in which FLC predicted relapse earlier than urine and serum immunofixation. Caldini A et al. Clin Chem Lab Med. 2015 Nov 18. pii: /j/cclm.ahead-of-print/cclm-2015-0689/cclm-2015-0689.xml. doi: 10.1515/cclm-2015-0689. [Epub ahead of print]. TLR4/TIRAP polymorphisms are associated with progression and survival of patients with symptomatic myeloma. Bagratuni T et al. Br J…

Emerging treatments

Oral Ixazomib Maintenance Therapy in Multiple Myeloma. Offidani M et al. Expert Rev Anticancer Ther. 2015 Nov 20. [Epub ahead of print]. Effective use of panobinostat in combination with other active agents in myeloma in a novel 5-drug combination: Case Report and Interesting Observations. Rajan AM et al. Am J Hematol. 2015 Nov 17. doi: 10.1002/ajh.24244. [Epub ahead of print]. Efficacy and safety of…

Biology and genetics

Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma. Weinhold N et al. Haematologica. 2015 Nov 26. pii: haematol.2015.136929. [Epub ahead of print]. Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Dykstra KM et al. Oncotarget. 2015 Nov 22. doi: 10.18632/oncotarget.6365. [Epub ahead of print]. The role of circulating miRNAs in multiple myeloma.…

General

Targeting Cyclin-Dependent Kinases and Cell Cycle Progression in Human Cancers. Santo L et al. Semin Oncol. 2015 Dec;42(6):788-800. doi: 10.1053/j.seminoncol.2015.09.024. Epub 2015 Sep 24. Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma in Older Adults. Guerard EJ et al. Clin Geriatr Med. 2016 Feb;32(1):191-205. doi: 10.1016/j.cger.2015.08.012. Epub 2015 Oct 9. Multiple myeloma and physical activity: a scoping review. Smith L et al. BMJ Open. 2015 Nov 27;5(11):e009576.…

Complications of myeloma and its treatments

A Report of 134 Newly Diagnosed Multiple Myeloma Patients with Renal Impairment. Liu A et al. Acta Haematol. 2015 Nov 21;135(3):140-145. [Epub ahead of print]. CD4(+)CD25(+) cells in multiple myeloma related renal impairment. Huang H et al. Sci Rep. 2015 Nov 13;5:16565. doi: 10.1038/srep16565. Complications after surgery for metastatic humeral lesions. Janssen SJ et al. J Shoulder Elbow Surg. 2015 Nov 4. pii: S1058-2746(15)00446-2. doi: 10.1016/j.jse.2015.08.009. [Epub ahead…

Current treatments

Evaluation of low-dose thalidomide as induction and maintenance therapy in patients with multiple myeloma not eligible for stem cell transplantation. Aznab M et al. Asia Pac J Clin Oncol. 2015 Nov 4. doi: 10.1111/ajco.12418. [Epub ahead of print]. Phase 3 trial of three thalidomide-containing regimens in patients with newly diagnosed multiple myeloma not transplant-eligible. Hungria VT et al. Ann Hematol. 2015 Oct 30. [Epub ahead…