Myeloma: diagnosis and management (Management and Treatment)

These guidelines, produced by the National Institute for Health and Care Excellence (NICE), set out new recommendations for the diagnosis, treatment and care of myeloma patients with the aim of providing consistently excellent patient-focused care within the NHS in England. Update information October 2018: Recommendations 1.8.13 to 1.8.17 were replaced by NICE’s guideline on venous thromboembolism in…

Recommendations for acquisition, interpretation and reporting of whole body low dose CT in patients with multiple myeloma and other plasma cell disorders: a report of the IMWG Bone Working Group

The Bone group of the IMWG present recommendations for the use of whole body low-dose CT in patients with myeloma and other plasma cell disorders, as an imaging method for assessing bone disease in these patients.

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Current treatments

Determining treatment intensity in elderly patients with multiple myeloma. Salvini M et al. Expert Rev Anticancer Ther. 2018 Sep. doi: 10.1080/14737140.2018.1496823. [Epub 2018 Jul 13] Treatment patterns and medication adherence among patients diagnosed with multiple myeloma and treated with panobinostat. Chari A et al. Future Oncol. 2018 Sep. doi: 10.2217/fon-2017-0727. [Epub 2018 May 30] Autologous stem cell transplantation in first…

General

The Multiple Myeloma Drug Pipeline-2018: A Review of Small Molecules and Their Therapeutic Targets. Abramson HN. Clin Lymphoma Myeloma Leuk. 2018 Sep. doi: 10.1016/j.clml.2018.06.015. [Epub 2018 Jun 18] A new conceptual framework for the therapy by optimized multidimensional pulses of therapeutic activity. The case of multiple myeloma model. Horvath D and Brutovsky B. J Theor Biol. 2018 Oct 7. doi: 10.1016/j.jtbi.2018.06.015. [Epub 2018 Jun…

Complications of myeloma and its treatments

Impact of elotuzumab treatment on pain and health-related quality of life in patients with relapsed or refractory multiple myeloma: results from the ELOQUENT-2 study. Cella D et al. Ann Hematol. 2018 Sep 4. doi: 10.1007/s00277-018-3469-4. [Epub ahead of print] Bilateral Angle Closure Following the Infusion of a Monoclonal Antibody to Treat Relapsing Multiple Myeloma. Lee AC et al. J…

Current treatments

Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients. Zadik Y. Oral Oncol. 2018 Sep. doi: 10.1016/j.oraloncology.2018.07.016. [Epub 2018 Jul 29.] Proteasome inhibitors for multiple myeloma. Okazuka K and Ishida T. Jpn J Clin Oncol. 2018 Sep 1. doi: 10.1093/jjco/hyy108. The Multiple Myeloma Drug Pipeline-2018: A Review of Small Molecules and Their Therapeutic Targets.…