Current treatments

A phase 2 study of bortezomib, cyclophosphamide, pegylated liposomal doxorubicin and dexamethasone for newly diagnosed multiple myeloma. Becker PS et al. Blood Cancer J. 2016 May 13;6:e422. doi: 10.1038/bcj.2016.31. Bendamustine, etoposide and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in patients with multiple myeloma. Green DJ et al. Bone Marrow Transplant. 2016 May 23. doi: 10.1038/bmt.2016.123. [Epub ahead of…

General

Italian consensus conference for the outpatient autologous stem cell transplantation management in multiple myeloma. Martino M et al. Bone Marrow Transplant. 2016 Apr 4. doi: 10.1038/bmt.2016.79. [Epub ahead of print]. Nuances in the Management of Older People With Multiple Myeloma. Pawlyn C et al. Curr Hematol Malig Rep. 2016 Apr 2. [Epub ahead of print]. Management of multiple myeloma in older adults: Gaining ground with…

Complications of myeloma and its treatments

Engraftment syndrome manifesting as acute brachial neuropathy following high-dose chemotherapy for management of plasma cell myeloma. Ninkovic S et al. Leuk Lymphoma. 2016 Apr 27:1-4. [Epub ahead of print]. A predictive tool particularly designed for elderly myeloma patients presenting with spinal cord compression. Rades D et al. BMC Cancer. 2016 Apr 25;16(1):292. doi: 10.1186/s12885-016-2325-y. A multicenter, retrospective epidemiologic survey of the clinical features and…

Current treatments

A phase II, single-arm, prospective study of bendamustine plus melphalan conditioning for second autologous stem cell transplantation in de novo multiple myeloma patients through a tandem transplant strategy. Martino M et al. Bone Marrow Transplant. 2016 Apr 18. doi: 10.1038/bmt.2016.94. [Epub ahead of print]. Comparison between intermittent and continuous spectra optia leukapheresis systems for autologous peripheral blood stem cell collection.…

General

Treatment of Multiple Myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group. Sonneveld P et al. Blood. 2016 Mar 21. pii: blood-2016-01-631200. [Epub ahead of print]. Panobinostat: A histone deacetylase inhibitor for the treatment of relapsed or refractory multiple myeloma. Wahaib K et al. Am J Health Syst Pharm. 2016 Apr 1;73(7):441-50. doi: 10.2146/ajhp150487. Haematological cancer: PomCyDex – a lower-cost option in refractory myeloma?…

Supportive care

Multiple myeloma presenting with acute bony spinal cord compression and mechanical instability successfully managed non-operatively. Gokaraju K et al. Spine J. 2016 Mar 17. pii: S1529-9430(16)00456-3. doi: 10.1016/j.spinee.2016.03.011. [Epub ahead of print]. Is balloon kyphoplasty safe and effective for cancer-related vertebral compression fractures with posterior vertebral body wall defects? Molloy S et al. J Surg Oncol. 2016 Mar 21. doi: 10.1002/jso.24222. [Epub…

Complications of myeloma and its treatments

International Myeloma Working Group Recommendations for the Diagnosis and Management of Myeloma-Related Renal Impairment. Dimopoulos MA et al. J Clin Oncol. 2016 Mar 14. pii: JCO650044. [Epub ahead of print]. Myeloma of the central nervous system – an ongoing conundrum! Harrison SJ et al. Leuk Lymphoma. 2016 Mar 21:1-2. [Epub ahead of print]. A case of multiple myeloma presenting as a distal renal tubular acidosis with extensive…

Current treatments

VTD is superior to VCD prior to intensive therapy in multiple myeloma: results of the prospective IFM2013-04 trial. Moreau P et al. Blood. 2016 Mar 21. pii: blood-2016-01-693580. [Epub ahead of print]. Intravenous (IV) bortezomib infusion after non-response to subcutaneous bortezomib administration can induce transitory responses in multiple myeloma patients: are some patients more sensitive to IV bortezomib? Gozzetti A et al. Br…

General

Allogeneic transplantation for multiple myeloma: yes, no or maybe? Bruno B et al. Bone Marrow Transplant. 2016 Feb 22. doi: 10.1038/bmt.2016.12. [Epub ahead of print]. Real-world outcome and healthcare costs of relapsed or refractory multiple myeloma: A retrospective analysis from the Chinese experience. Zhou X et al. Hematology. 2016 Feb 22. [Epub ahead of print]. Practical Approaches to the Management of Dual Refractory Multiple…