General

Living with the burden of relapse in multiple myeloma from the patient and physician perspective. Hulin C et al. Leuk Res. 2017 May 31;59:75-84. doi: 10.1016/j.leukres.2017.05.019. [Epub ahead of print]. The impact of comorbidity on mortality in multiple myeloma: a Danish nationwide population-based study. Gregersen H et al. Cancer Med. 2017 Jun 22. doi: 10.1002/cam4.1128. [Epub ahead of print]. Recent advances in understanding multiple myeloma.…

Supportive treatments

Comparison of the CELLEX™ and UVAR-XTS™ closed-system extracorporeal photopheresis devices in the treatment of chronic graft-versus-host disease. Whittle RM et al. J Clin Apher. 2017 Jun 13. doi: 10.1002/jca.21541. [Epub ahead of print]. Comparison of Operative Time with Conventional Fluoroscopy versus Spinal Neuronavigation in Instrumented Spinal Tumor Surgery. Miller JA et al. World Neurosurg. 2017 Jun 9. pii: S1878-8750(17)30908-7. doi: 10.1016/j.wneu.2017.06.016.…

Complications of myeloma and its treatments

Molecular mechanisms, current management and next generation therapy in myeloma bone disease. Heusschen R et al. Leuk Lymphoma. 2017 Jun 2:1-15. doi: 10.1080/10428194.2017.1323272. [Epub ahead of print]. An unusual presentation of multiple myeloma with unilateral sudden vision loss: A case report. Wu PW et al. Medicine (Baltimore). 2017 Jun;96(25):e7277. doi: 10.1097/MD.0000000000007277. Metabolic Syndrome in Long-Term Survivors of Hematopoietic Stem-Cell Transplantation. Ragbourne SC et al. Clin Lymphoma Myeloma Leuk. 2017 Jun;17(6):340-346.…

Current treatments

Comparison of cyclophosphamide-thalidomide-dexamethasone to bortezomib-cyclophosphamide-dexamethasone as induction therapy for multiple myeloma patients in Brazil. Vigolo S et al. Hematol Oncol Stem Cell Ther. 2017 Jun 15. pii: S1658-3876(17)30082-1. doi: 10.1016/j.hemonc.2017.05.027. [Epub ahead of print]. Long-term health-related quality of life in transplant-ineligible patients with newly diagnosed multiple myeloma receiving lenalidomide and dexamethasone. Vogl DT et al. Leuk Lymphoma. 2017 Jun 22:1-8. doi: 10.1080/10428194.2017.1334125. [Epub ahead of…

Publication of consensus statement on the use of plerixafor in myeloma or lymphoma patients

A consensus statement identifying the best use of plerixafor to facilitate autologous peripheral stem cell collection to support high-dose therapy and stem cell transplantation in myeloma or lymphoma patients has been published recently in the Journal of Clinical Apheresis. Written by the Plerixafor Usage Working Party Group involving representative clinicians from the UK and Republic…

NICE recommends carfilzomib for restricted use in England and Wales

The National Institute for Health and Care Excellence (NICE) has published a final appraisal determination (FAD) recommending the use of carfilzomib (Kyprolis®) in combination with dexamethasone for myeloma patients at first relapse who have not previously received bortezomib (Velcade®). Carfilzomib will immediately be available to eligible patients in England via interim funding arrangements through the…

IMWG publishes consensus on second primary malignancies in myeloma

The International Myeloma Working Group (IMWG) has published a consensus statement providing practical recommendations for managing myeloma patients who develop second primary malignanices (SPMs). Published in the Annals of Oncology, the group reviewed the latest evidence of possible host-, disease- and treatment-related risk factors for the development of SPMs in myeloma patients. They recommend that…

General

Experiences of establishing an academic early phase clinical trials unit. Brown SR et al. Clin Trials. 2017 May 1:1740774517710250. doi: 10.1177/1740774517710250. [Epub ahead of print]. Minimal Residual Disease Negativity Is a New End Point of Myeloma Therapy. Harousseau JL et al. J Clin Oncol. 2017 May 19:JCO2017731331. doi: 10.1200/JCO.2017.73.1331. [Epub ahead of print]. Race colors transplantation utilization for multiple myeloma. Majhail NS et al. Cancer. 2017 May…

Supportive treatments

Variability of high-dose melphalan exposure on oral mucositis in patients undergoing prophylactic low-level laser therapy.
Rodrigues GH et al. Lasers Med Sci. 2017 May 16. doi: 10.1007/s10103-017-2211-0. [Epub ahead of print].

G-CSF improves safety when you start the day after autologous transplant in multiple myeloma.
Sborov DW et al. Leuk Lymphoma. 2017 May 16:1-5. doi: 10.1080/10428194.2017.1318436. [Epub ahead of print].