Diagnostic tests and prognostic indicators

Minimal Residual Disease Assessment in the Context of Multiple Myeloma Treatment. Nishihori T et al. Curr Hematol Malig Rep. 2016 Feb 22. [Epub ahead of print]. Fully automated classification of bone marrow infiltration in low-dose CT of patients with multiple myelomabased on probabilistic density model and supervised learning. Martínez-Martínez F et al. Comput Biol Med. 2016 Feb 8;71:57-66. doi: 10.1016/j.compbiomed.2016.02.001. [Epub ahead of print].…

Related conditions

Smoldering Multiple Myeloma: Emerging Concepts and Therapeutics. Sundararajan S et al. Curr Hematol Malig Rep. 2016 Feb 19. [Epub ahead of print]. Clinical characteristics and outcomes in biclonal gammopathies. Mullikin TC et al. Am J Hematol. 2016 Feb 3. doi: 10.1002/ajh.24319. [Epub ahead of print]. Trachyonychia as the presenting sign of myeloma-associated amyloidosis. Shim JH et al. Int J Dermatol. 2016 Feb 12. doi: 10.1111/ijd.13240. [Epub…

Emerging treatments

A practical review on carfilzomib in multiple myeloma. Muchtar E et al. Eur J Haematol. 2016 Feb 19. doi: 10.1111/ejh.12749. [Epub ahead of print]. Monoclonal antibody therapy in multiple myeloma: where do we stand and where are we going Thanendrarajan S et al. Immunotherapy. 2016 Feb 17. [Epub ahead of print]. Siltuximab (CNTO 328) with lenalidomide, bortezomib and dexamethasone in newly-diagnosed, previously untreated multiple…

Biology and genetics

USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells. Jin Y et al. Biomed Pharmacother. 2016 Mar;78:264-71. doi: 10.1016/j.biopha.2016.01.012. Epub 2016 Feb 2. Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats. Al-Harbi NO et al. Toxicol Mech Methods. 2016 Feb 21:1-7. [Epub ahead of print]. Distinct lncRNA transcriptional fingerprints characterize progressive stages…

General

Allogeneic transplantation for multiple myeloma: yes, no or maybe? Bruno B et al. Bone Marrow Transplant. 2016 Feb 22. doi: 10.1038/bmt.2016.12. [Epub ahead of print]. Real-world outcome and healthcare costs of relapsed or refractory multiple myeloma: A retrospective analysis from the Chinese experience. Zhou X et al. Hematology. 2016 Feb 22. [Epub ahead of print]. Practical Approaches to the Management of Dual Refractory Multiple…

Supportive care

A comparison of the efficacy of piperacillin-tazobactam and cefoperazone-sulbactam therapies in the empirical treatment of patients with febrile neutropenia. Aynioglu A et al. Rev Esp Quimioter. 2016 Feb 16. pii: aynur16feb2016. [Epub ahead of print]. Retained needle after cement injection during vertebral augmentation and its management strategy. Kosse A et al. BMJ Case Rep. 2016 Feb 18;2016. pii: bcr2015012180. doi: 10.1136/bcr-2015-012180.…

Complications of myeloma and its treatments

Low serum vitamin D occurs commonly among multiple myeloma patients treated with bortezomib and/or thalidomide and is associated with severe neuropathy. Wang J et al. Support Care Cancer. 2016 Feb 23. [Epub ahead of print]. Early Postoperative Outcomes After Total Joint Arthroplasty in Patients With Multiple Myeloma. Menendez ME et al. J Arthroplasty. 2016 Jan 29. pii: S0883-5403(16)00091-7. doi:10.1016/j.arth.2016.01.029. [Epub ahead of print]. Bortezomib-based…

Current treatments

A phase 2 study of three low-dose intensity subcutaneous Bortezomib regimens in elderly frail patients with untreated multiple myeloma. Larocca A et al. Leukemia. 2016 Feb 22. doi: 10.1038/leu.2016.36. [Epub ahead of print]. A single-center retrospective analysis of first-line therapy of multiple myeloma with bendamustine-bortezomib-dexamethasone. Zwickl H et al. Leuk Lymphoma. 2016 Feb 22:1-6. [Epub ahead of print]. Stem Cell Harvesting after Bortezomib-Based Reinduction…

Diagnostic tests and prognostic indicators

Prospective comparison of conventional radiography, low-dose computed tomography and magnetic resonance imaging in monoclonal gammopathies. Minarik J et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Jan 5. doi: 10.5507/bp.2015.064. [Epub ahead of print]. Interference of daratumumab in monitoring multiple myeloma patients using serum immunofixation electrophoresis can be abrogated using the daratumumab IFE reflex assay (DIRA). van…