Related conditions

Fatal Cryocrystalglobulinemia With Intravascular and Renal Tubular Crystalline Deposits. DeLyria PA et al. Am J Kidney Dis. 2016 Jan 14. pii: S0272-6386(15)01431-6. doi: 10.1053/j.ajkd.2015.11.014. [Epub ahead of print]. Outcome of Patients with Systemic Light chain (AL) Amyloidosis with Concurrent Renal and Cardiac Involvement. Badar T et al. Eur J Haematol. 2016 Jan 16. doi: 10.1111/ejh.12736. [Epub ahead of print]. Multiple qualitative and…

Emerging treatments

Spotlight on ixazomib: potential in the treatment of multiple myeloma. Muz B et al. Drug Des Devel Ther. 2016 Jan 11;10:217-26. doi: 10.2147/DDDT.S93602. eCollection 2016. Immune Checkpoint Blockade in Lymphoid Malignancies. Thanarajasingam G et al, FEBS J. 2016 Jan 25. doi: 10.1111/febs.13668. [Epub ahead of print]. Elotuzumab: First Global Approval. Markham A. Drugs. 2016 Jan 26. [Epub ahead of print]. TAK-228 (formerly MLN0128), an…

Biology and genetics

Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma. Johnson DC et al. Nat Commun. 2016 Jan 8;7:10290. doi: 10.1038/ncomms10290. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Zhang Z et al. Oncotarget. 2016 Jan 22. doi: 10.18632/oncotarget.6974. [Epub ahead of print]. Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells. Bartee…

General

Multiple Myeloma: Diagnosis and Treatment. Rajkumar SV et al. Mayo Clin Proc. 2016 Jan;91(1):101-19. doi: 10.1016/j.mayocp.2015.11.007. Management of relapsed multiple myeloma: Recommendations of the international myeloma working group. Laubach J et al. Leukemia. 2015 Dec 29. doi: 10.1038/leu.2015.356. [Epub ahead of print]. First hematopoietic cell transplantation in Uzbekistan: Progress through education and cooperation. Karimov K et al. Transfus Apher Sci. 2016 Jan 12. pii: S1473-0502(16)00016-1. doi: 10.1016/j.transci.2016.01.014.…

Supportive care

Comparison of unilateral versus bilateral percutaneous kyphoplasty for the treatment of patients with osteoporosis vertebral compression fracture (OVCF): a systematic review and meta-analysis. Cheng X et al.  Eur Spine J. 2016 Jan 27. [Epub ahead of print]. Pathophysiology of Metastatic Bone Disease and the Role of the Second Generation of Bisphosphonates:From Basic Science to Medicine. Barghash RF et…

Complications of myeloma and its treatments

Retrospective study of the incidence and patterns of arterial and venous thrombosis in Chinese versus African American patients with multiple myeloma. Raghupathy R et al. Br J Haematol. 2016 Jan 26. doi: 10.1111/bjh.13942. [Epub ahead of print]. Adventitious sporulation in Fusarium: The yeast that were not. Lockwood MB et al. IDCases. 2015 Dec 17;3:5-7. doi: 10.1016/j.idcr.2015.10.004. eCollection 2016. Bone Disease in Myeloma: The…

Current treatments

Triplet vs doublet lenalidomide-containing regimens for the treatment of elderly patients with newly diagnosed multiple myeloma. Magarotto V et al. Blood. 2016 Jan 4. pii: blood-2015-08-662627. [Epub ahead of print]. Lenalidomide plus melphalan and prednisone, followed by lenalidomide maintenance versus thalidomide plus melphalan and prednisone, followed by thalidomide maintenance; results of the randomised phase 3 HOVON 87/NMSG18 trial.…

Supportive care

Percutaneous vertebroplasty for patients with metastatic compression fractures of the thoracolumbar spine: clinical and radiological factors affecting functional outcomes. Bae JW et al. Spine J. 2015 Dec 2. pii: S1529-9430(15)01694-0. doi: 10.1016/j.spinee.2015.11.033. [Epub ahead of print]. Bone Marker-Directed Dosing of Zoledronic Acid for the Prevention of Skeletal Complications in Patients With Multiple Myeloma: Results of the Z-MARK Study.…

Current treatments

Favorable long-term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non-myeloablative allogeneic transplantation. Ahmad I et al. Bone Marrow Transplant. 2015 Dec 21. doi: 10.1038/bmt.2015.319. [Epub ahead of print]. Phase I/II trial of Weekly Bortezomib with Lenalidomide and Dexamethasone in First Relapse or Primary Refractory Myeloma. Broijl A et al. Haematologica. 2015 Dec 11. pii: haematol.2015.132431. [Epub ahead…

Diagnostic tests and prognostic indictors

Imaging features of haematological malignancies of kidneys. Sandrasegaran K et al. Clin Radiol. 2015 Dec 11. pii: S0009-9260(15)00444-4. doi: 10.1016/j.crad.2015.11.007. [Epub ahead of print]. Minimal tumour burden in haematological diseases: a step forward with quantitative assessment of Bence-Jones in nephelometry? Pieri M et al. Br J Haematol. 2015 Dec 18. doi: 10.1111/bjh.13878. [Epub ahead of print]. ANNALS EXPRESS: Low IgA levels…