Biology and genetics

Proteasome function is required for platelet production. Shi DS et al. J Clin Invest. 2014 Jul 25. pii: 75247. doi: 10.1172/JCI75247. [Epub ahead of print]. Overexpression of CYR61/CCN1 in the multiple myeloma microenvironment is associated with superior survival and prevention of bone disease. Johnson SK et al. Blood. 2014 Jul 24. pii: blood-2014-02-555813. [Epub ahead…

Complications of myeloma and its treatments

A Rare Concurrence: Nonischemic Cardiomyopathy and Multiple Myeloma Without Amyloidosis. Gupta T et al. Am J Med. 2014 Jul 21. pii: S0002-9343(14)00592-0. doi: 10.1016/j.amjmed.2014.07.012. [Epub ahead of print]. Incidence of Pneumocystis jiroveci Pneumonia among Groups at Risk in HIV-negative Patients. Fillatre P et al. Am J Med. 2014 Jul 21. pii: S0002-9343(14)00590-7. doi: 10.1016/j.amjmed.2014.07.010. [Epub…

Current treatments

Bortezomib-thalidomide-based regimens improved clinical outcomes without increasing toxicity as induction treatment for untreated multiple myeloma: A meta-analysis of phase III randomized controlled trials. Huang H et al. Leuk Res. 2014 Jun 30. pii: S0145-2126(14)00188-X. doi: 10.1016/j.leukres.2014.06.009. [Epub ahead of print]. Long-term survival with cyclophosphamide, bortezomib and dexamethasone induction therapy in patients with newly diagnosed multiple…