The Scottish Medicines Consortium (SMC) has approved the use of daratumumab (Darzalex®) monotherapy as a fourth line treatment option for relapsed and refractory myeloma patients in Scotland, who have previously received treatment with a proteasome inhibitor and immunomodulatory drug. This decision is based on the pooled analysis of results from two clinical trials, MMY2002 and…
A study, funded by Myeloma UK, has identified a link between overexpression of EZH2 and high risk myeloma. The results, published in the Blood Cancer Journal, demonstrate that patients with high levels of EZH2 expression had shorter overall survival and response to treatment compared to patients with low levels of EZH2 expression, regardless of treatment.…
Acupuncture for reduction of symptom burden in multiple myelomapatients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial. Deng G et al. Support Care Cancer. 2017 Sep 17. doi: 10.1007/s00520-017-3881-7. [Epub ahead of print]. The treatment of paraprotein-related kidney disease. Hutchison CA et al. Curr Opin Nephrol Hypertens. 2017 Sep 6. doi: 10.1097/MNH.0000000000000369. [Epub ahead of print]. Surgical Roles for Spinal…
Chimeric antigen receptor T-cell therapy – assessment and management of toxicities. Neelapu SS et al. Nat Rev Clin Oncol. 2017 Sep 19. doi: 10.1038/nrclinonc.2017.148. [Epub ahead of print]. Chimeric Antigen Receptor T-cell Therapies for Multiple Myeloma. Mikkilineni L et al. Blood. 2017 Sep 19. pii: blood-2017-06-793869. doi: 10.1182/blood-2017-06-793869. [Epub ahead of print]. Checking in: T cells against multiple myeloma. Kumar SK. Blood. 2017 Sep 7;130(10):1175-1176.…
Stem cell mobilization in patients with dialysis-dependent multiple myeloma: Report of the Polish Myeloma Study Group. Waszczuk-Gajda A et al. J Clin Apher. 2017 Sep 18. doi: 10.1002/jca.21584. [Epub ahead of print]. Autologous hematopoietic cell transplantation for multiple myelomapatients with renal insufficiency: a center for international blood and marrow transplant research analysis. Mahindra A et al. Bone Marrow Transplant. 2017 Sep 18. doi: 10.1038/bmt.2017.198. [Epub…
Plasma Cell Infiltration of the Kidney as a Manifestation of Myeloma: A Report of Three Cases. Kaur T et al. Indian J Nephrol. 2017 Sep-Oct;27(5):395-398. doi: 10.4103/ijn.IJN_215_16. Incidence of Contrast-Induced Nephropathy in Patients with Multiple Myeloma Undergoing Contrast-Enhanced Procedures. Crowley MP et al. Pathol Oncol Res. 2017 Sep 13. doi: 10.1007/s12253-017-0300-9. [Epub ahead of print]. Multiple Myeloma Presenting as Massive Amyloid Deposition in a Parathyroid…
A recent study, conducted by the International Myeloma Working Group (IMWG), has demonstrated the benefits of whole body computed tomography (WBCT) compared to conventional skeletal survey (CSS) for identifying osteolytic lesions in myeloma. The study, published in Blood Cancer Journal, found that WBCT is more sensitive than CSS in detecting skeletal lesions, with 20-25% patients…
A study, funded by Myeloma UK, has demonstrated that neutral tumour evolution in myeloma is associated with poorer prognosis. Neutral evolution is the term used to describe evolution caused by random genetic mutations and are normally considered to be neither beneficial nor detrimental to survival. However, in this study, such tumours conferred a worse prognosis…
Oncological and functional results of the surgical treatment of vertebral metastases in patients with multiple myeloma. Guzik G et al. BMC Surg. 2017 Aug 23;17(1):92. doi: 10.1186/s12893-017-0288-9. Kidney Transplantation in Patients With Active Multiple Myeloma: Case Reports. Lum EL et al. Transplant Direct. 2017 Jul 21;3(8):e200. doi: 10.1097/TXD.0000000000000716. eCollection 2017 Aug. Bisphosphonate guidelines for treatment and prevention of myeloma bone disease. Lee OL et al. Intern Med…
Therapeutic monoclonal antibodies in combination with pomalidomide can overcome refractoriness to both agents in multiple myeloma: A case-based approach. Baertsch MA et al. Hematol Oncol. 2017 Aug 25. doi: 10.1002/hon.2473. [Epub ahead of print]. Evolutionary biology of high-risk multiple myeloma. Pawlyn C et al. Nat Rev Cancer. 2017 Aug 24;17(9):543-556. doi: 10.1038/nrc.2017.63. Comprehensive Evaluation of the Revised International Staging System in Multiple Myeloma Patients…