Emerging treatments

Ricolinostat plus lenalidomide, and dexamethasone in relapsed or refractory multiple myeloma: a multicentre phase 1b trial. Yee AJ et al. Lancet Oncol. 2016 Sep 16. pii: S1470-2045(16)30375-8. doi: 10.1016/S1470-2045(16)30375-8. [Epub ahead of print]. A selective histone deacetylase inhibitor for myeloma. Pratt G et al. Lancet Oncol. 2016 Sep 16. pii: S1470-2045(16)30407-7. doi: 10.1016/S1470-2045(16)30407-7. [Epub ahead of print]. Vemurafenib in combination with cobimetinib in…

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Biology and genetics

Outcome of Patients with Multiple Myeloma and CKS1B Gene Amplification after Autologous Hematopoietic Stem Cell Transplantation. Bock F et al. Biol Blood Marrow Transplant. 2016 Sep 13. pii: S1083-8791(16)30329-9. doi: 10.1016/j.bbmt.2016.09.003. [Epub ahead of print]. Outcomes in patients with multiple myeloma with TP53 deletion after autologous hematopoietic stem cell transplant. Gaballa S et al. Am J Hematol. 2016 Oct;91(10):E442-7. doi: 10.1002/ajh.24487. Epub 2016 Sep 3.…

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General

Advances in understanding prognosis in myeloma. Smith D et al. Br J Haematol. 2016 Sep 8. doi: 10.1111/bjh.14304. [Epub ahead of print]. Stem Cell Transplantation In Multiple Myeloma. Offidani M et al. Curr Cancer Drug Targets. 2016 Sep 19. [Epub ahead of print]. The role of high-dose melphalan and autologous stem cell transplant in the rapidly evolving era of modernmultiple myeloma therapy. Voorhees PM et…

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Supportive care

Therapeutic drug monitoring enables safe and effective lenalidomide therapy in patients with multiple myeloma on hemodialysis. Kobayashi T et al. Ann Hematol. 2016 Sep 6. [Epub ahead of print]. Mid-term outcomes after radiofrequency-targeted vertebral augmentation in the treatment of myeloma associated vertebral fractures. Ali T et al. Technol Health Care. 2016 Sep 14;24(5):745-51. doi: 10.3233/THC-161222. Pharmacokinetics of Cefepime in Patients with Cancer and Febrile…

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Complications of myeloma and its treatments

Pathological Fracture In Odontoid Process In Multiple Myeloma. Demirci U et al. Turk J Haematol. 2016 Sep 23. doi: 10.4274/tjh.2016.0020. [Epub ahead of print]. Pinpointing a Factor in Myeloma Bone Disease. [No authors listed]. Cancer Discov. 2016 Sep 22. [Epub ahead of print]. Renal Toxicities of Novel Agents Used for Treatment of Multiple Myeloma. Wanchoo R et al. Clin J Am Soc Nephrol. 2016 Sep 21. pii:…

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Current treatments

Upfront autologous stem cell transplantation for newly diagnosed elderly multiple myeloma patients: a prospective multicenter study. Garderet L et al. Haematologica. 2016 Sep 9. pii: haematol.2016.150334. [Epub ahead of print]. Outcome with lenalidomide plus dexamethasone followed by early autologous stem cell transplantation in patients with newly diagnosed multiple myeloma on the ECOG-ACRIN E4A03 randomized clinical trial: long-term follow-up. Biran N et al. Blood Cancer…

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Study reveals prevalence of symptoms in myeloma patients

A Myeloma UK funded study, published recently in the European Journal of Haematology, has found that a large number of symptoms occur frequently in myeloma patients, highlighting the importance of routine assessments throughout the disease trajectory in order to achieve optimal quality of life for patients. Led by Christina Ramsenthaler and Prof Irene Higginson, Department of…

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Diagnostic tests and prognostic indicators

IFM (Intergroupe francophone du myélome) recommendations for uniform interpretation of serum and urine protein electrophoresis in multiple myeloma diagnosis and follow-up. Dejoie T et al. Ann Biol Clin (Paris). 2016 Aug 1;74(4):429-441. Application of PET/CT in treatment response evaluation and recurrence prediction in patients with newly-diagnosed multiple myeloma. Li Y et al. Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11418. [Epub ahead of print]. The independent…

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Related conditions

Gastric Outlet Obstruction due to Gastrointestinal Amyloidosis. Cohen JA et al. J Gastrointest Surg. 2016 Aug 19. [Epub ahead of print]. Paraprotein-Related Kidney Disease: Diagnosing and Treating Monoclonal Gammopathy of Renal Significance. Rosner MH et al. Clin J Am Soc Nephrol. 2016 Aug 15. pii: CJN.02920316. [Epub ahead of print]. Primary pulmonary plasmacytoma: a case report introduction. Nie S et al. World J…

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