Biology and genetics

Targeting proteasome ubiquitin receptor Rpn13 in multiple myeloma. Song Y et al. Leukemia. 2016 May 20. doi: 10.1038/leu.2016.97. [Epub ahead of print]. Daratumumab depletes CD38+ immune-regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma. Krejcik J et al. Blood. 2016 May 24. pii: blood-2015-12-687749. [Epub ahead of print]. Unusual cytological features in multiple myeloma. Abdulsalam AH et al. Am J Hematol. 2016 May 24.…

General

NCCN Guidelines Update for Multiple Myeloma. Anderson KC. J Natl Compr Canc Netw. 2016 May;14(5 Suppl):675-7. Allogeneic hematopoietic cell transplantation for multiple myeloma in Europe: trends and outcomes over 25 years. A study by the EBMT Chronic Malignancies Working Party. Sobh M et al. Leukemia. 2016 May 20. doi: 10.1038/leu.2016.101. [Epub ahead of print]. Cost-effectiveness of adding carfilzomib to lenalidomide and dexamethasone in…

Supportive care

Does the choice of thrombotic prophylactic drug depend on the known risk factors of patients with multiple myeloma in clinical practice? Chalayer E et al.Thromb Res. 2016 May 7;143:101-102. doi: 10.1016/j.thromres.2016.05.003. [Epub ahead of print]. Impact of High-Cut-Off Dialysis on Renal Recovery in Dialysis-Dependent Multiple Myeloma Patients: Results from a Case-Control Study. Gerth HU et al. PLoS One. 2016 May 6;11(5):e0154993. doi: 10.1371/journal.pone.0154993. eCollection…

Complications of myeloma and its treatments

Complications After Surgical Management of Proximal Femoral Metastasis: A Retrospective Study of 417 Patients. Janssen SJ et al. J Am Acad Orthop Surg. 2016 May 25. [Epub ahead of print]. Renal impairment in multiple myeloma: A single center experience. Gorsane I et al. Saudi J Kidney Dis Transpl. 2016 May-Jun;27(3):480-5. doi: 10.4103/1319-2442.182380. A review of the Venous Thrombotic Issues associated with Multiple Myeloma.…

Current treatments

A phase 2 study of bortezomib, cyclophosphamide, pegylated liposomal doxorubicin and dexamethasone for newly diagnosed multiple myeloma. Becker PS et al. Blood Cancer J. 2016 May 13;6:e422. doi: 10.1038/bcj.2016.31. Bendamustine, etoposide and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in patients with multiple myeloma. Green DJ et al. Bone Marrow Transplant. 2016 May 23. doi: 10.1038/bmt.2016.123. [Epub ahead of…

Diagnostic tests and prognostic indicators

Minimal residual disease monitoring and immune profiling using second generation flow cytometry in elderlymultiple myeloma. Paiva B et al. Blood. 2016 Apr 26. pii: blood-2016-03-705319. [Epub ahead of print]. Development and Validation of Electrochemiluminescence Assays to Measure Free and Total sSLAMF7 in Human Serum in the Absence and Presence of Elotuzumab. Postelnek J et al. AAPS J. 2016 Apr 26. [Epub…

Related conditions

Laboratory testing in monoclonal gammopathy of renal significance (MGRS). Leung N et al. Clin Chem Lab Med. 2016 Apr 23. pii: /j/cclm.ahead-of-print/cclm-2015-0994/cclm-2015-0994.xml. doi: 10.1515/cclm-2015-0994. [Epub ahead of print]. Can We Cure Light Chain Deposition Disease of the Kidneys?-A Review and Case Report of a Patient Treated With a Triple Transplant Approach. Sivaraj D et al. Clin Lymphoma Myeloma Leuk. 2016 Mar 29. pii:…

Emerging treatments

Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma. Moreau P et al. N Engl J Med. 2016 Apr 28;374(17):1621-1634. Exposure-safety-efficacy analysis of single-agent ixazomib, an oral proteasome inhibitor, in relapsed/refractorymultiple myeloma: dose selection for a phase 3 maintenance study. Gupta N et al. Invest New Drugs. 2016 Apr 2. [Epub ahead of print]. Phase 1 Clinical Trial of Marizomib (NPI-0052) in Patients…

Biology and genetics

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease. Fu J et al. J Clin Invest. 2016 Apr 4. pii: 80276. doi: 10.1172/JCI80276. [Epub ahead of print]. Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients. Bieghs L et al. PLoS One. 2016 Apr 25;11(4):e0154256. doi: 10.1371/journal.pone.0154256. eCollection 2016. Assessment of tumoral plasma cells in apheresis products for autologous stem…

General

Italian consensus conference for the outpatient autologous stem cell transplantation management in multiple myeloma. Martino M et al. Bone Marrow Transplant. 2016 Apr 4. doi: 10.1038/bmt.2016.79. [Epub ahead of print]. Nuances in the Management of Older People With Multiple Myeloma. Pawlyn C et al. Curr Hematol Malig Rep. 2016 Apr 2. [Epub ahead of print]. Management of multiple myeloma in older adults: Gaining ground with…