Emerging treatments

A practical review on carfilzomib in multiple myeloma. Muchtar E et al. Eur J Haematol. 2016 Feb 19. doi: 10.1111/ejh.12749. [Epub ahead of print]. Monoclonal antibody therapy in multiple myeloma: where do we stand and where are we going Thanendrarajan S et al. Immunotherapy. 2016 Feb 17. [Epub ahead of print]. Siltuximab (CNTO 328) with lenalidomide, bortezomib and dexamethasone in newly-diagnosed, previously untreated multiple…

Biology and genetics

USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells. Jin Y et al. Biomed Pharmacother. 2016 Mar;78:264-71. doi: 10.1016/j.biopha.2016.01.012. Epub 2016 Feb 2. Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats. Al-Harbi NO et al. Toxicol Mech Methods. 2016 Feb 21:1-7. [Epub ahead of print]. Distinct lncRNA transcriptional fingerprints characterize progressive stages…

General

Allogeneic transplantation for multiple myeloma: yes, no or maybe? Bruno B et al. Bone Marrow Transplant. 2016 Feb 22. doi: 10.1038/bmt.2016.12. [Epub ahead of print]. Real-world outcome and healthcare costs of relapsed or refractory multiple myeloma: A retrospective analysis from the Chinese experience. Zhou X et al. Hematology. 2016 Feb 22. [Epub ahead of print]. Practical Approaches to the Management of Dual Refractory Multiple…

Supportive care

A comparison of the efficacy of piperacillin-tazobactam and cefoperazone-sulbactam therapies in the empirical treatment of patients with febrile neutropenia. Aynioglu A et al. Rev Esp Quimioter. 2016 Feb 16. pii: aynur16feb2016. [Epub ahead of print]. Retained needle after cement injection during vertebral augmentation and its management strategy. Kosse A et al. BMJ Case Rep. 2016 Feb 18;2016. pii: bcr2015012180. doi: 10.1136/bcr-2015-012180.…

Complications of myeloma and its treatments

Low serum vitamin D occurs commonly among multiple myeloma patients treated with bortezomib and/or thalidomide and is associated with severe neuropathy. Wang J et al. Support Care Cancer. 2016 Feb 23. [Epub ahead of print]. Early Postoperative Outcomes After Total Joint Arthroplasty in Patients With Multiple Myeloma. Menendez ME et al. J Arthroplasty. 2016 Jan 29. pii: S0883-5403(16)00091-7. doi:10.1016/j.arth.2016.01.029. [Epub ahead of print]. Bortezomib-based…

Current treatments

A phase 2 study of three low-dose intensity subcutaneous Bortezomib regimens in elderly frail patients with untreated multiple myeloma. Larocca A et al. Leukemia. 2016 Feb 22. doi: 10.1038/leu.2016.36. [Epub ahead of print]. A single-center retrospective analysis of first-line therapy of multiple myeloma with bendamustine-bortezomib-dexamethasone. Zwickl H et al. Leuk Lymphoma. 2016 Feb 22:1-6. [Epub ahead of print]. Stem Cell Harvesting after Bortezomib-Based Reinduction…

Diagnostic tests and prognostic indicators

Prospective comparison of conventional radiography, low-dose computed tomography and magnetic resonance imaging in monoclonal gammopathies. Minarik J et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Jan 5. doi: 10.5507/bp.2015.064. [Epub ahead of print]. Interference of daratumumab in monitoring multiple myeloma patients using serum immunofixation electrophoresis can be abrogated using the daratumumab IFE reflex assay (DIRA). van…

Related conditions

Fatal Cryocrystalglobulinemia With Intravascular and Renal Tubular Crystalline Deposits. DeLyria PA et al. Am J Kidney Dis. 2016 Jan 14. pii: S0272-6386(15)01431-6. doi: 10.1053/j.ajkd.2015.11.014. [Epub ahead of print]. Outcome of Patients with Systemic Light chain (AL) Amyloidosis with Concurrent Renal and Cardiac Involvement. Badar T et al. Eur J Haematol. 2016 Jan 16. doi: 10.1111/ejh.12736. [Epub ahead of print]. Multiple qualitative and…

Emerging treatments

Spotlight on ixazomib: potential in the treatment of multiple myeloma. Muz B et al. Drug Des Devel Ther. 2016 Jan 11;10:217-26. doi: 10.2147/DDDT.S93602. eCollection 2016. Immune Checkpoint Blockade in Lymphoid Malignancies. Thanarajasingam G et al, FEBS J. 2016 Jan 25. doi: 10.1111/febs.13668. [Epub ahead of print]. Elotuzumab: First Global Approval. Markham A. Drugs. 2016 Jan 26. [Epub ahead of print]. TAK-228 (formerly MLN0128), an…