Biology and genetics

Autophagy in Plasma Cell Pathophysiology. Oliva L et al. Front Immunol. 2014 Mar 12;5:103. eCollection 2014. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Olsen OE et al. Blood Cancer J. 2014 Mar 21;4:e196. doi: 10.1038/bcj.2014.16. Phenotypic, Genomic and Functional Characterization Reveals No Differences between CD138++…

General

Survival of Multiple Myeloma Patients Aged 65-70 Years in the Era of Novel Agents and Autologous Stem Cell Transplantation. A Multicenter Retrospective Collaborative Study of the Japanese Society of Myeloma and the European Myeloma Network. Ozaki S et al. Acta Haematol. 2014 Mar 22;132(2):211-219. [Epub ahead of print]. Pathways for blood and bowel cancer patients…

Emerging treatments

A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma. Korde N et al. Haematologica. 2014 Mar 21. [Epub ahead of print]. Sotatercept in patients with osteolytic lesions of multiple myeloma. Abdulkadyrov KM et al. Br J Haematol. 2014 Mar 21. doi: 10.1111/bjh.12835. [Epub ahead of print]. Evolution of carfilzomib dose and…

Supportive care

Pharmacoeconomic analysis of palifermin to prevent mucositis among patients undergoing autologous hematopoietic stem cell transplantation.
Nooka AK et al. Biol Blood Marrow Transplant. 2014 Mar 6. pii: S1083-8791(14)00148-7. doi: 10.1016/j.bbmt.2014.02.025. [Epub ahead of print].

Plasma Exchange for Kidney Disease: What Is the Best Evidence?
Hildebrand AM et al. Adv Chronic Kidney Dis. 2014 Mar;21(2):217-227. doi: 10.1053/j.ackd.2014.01.008.

Current treatments

Partial Response at Completion of Bortezomib-Thalidomide-Dexamethasone (VTd) Induction Regimen Upfront in Multiple Myeloma Does Not Preclude Response to VTd in Consolidation.Fouquet G et al. J Cancer. 2014 Mar 11;5(3):248-52. doi: 10.7150/jca.8541. eCollection 2014Thalidomide, clarithromycin, lenalidomide and dexamethasone therapy in newly diagnosed, symptomatic multiple myeloma.Mark TM et al. Leuk Lymphoma. 2014 Mar 25. [Epub ahead of…

Related conditions

The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network. van de Donk NW et al. Haematologica. 2014 Mar 21. [Epub ahead of print]. A case of CD138-/CD19+/CD4+ IgD plasma cell leukemia. Sorigue M et al. Cytometry B Clin Cytom. 2014 Mar 22. doi: 10.1002/cytob.21173.…

Supportive care

The Pharmacokinetics and Pharmacodynamics of Denosumab in Patients with Advanced Solid Tumours and Bone Metastases: A Systematic Review. Sohn W et al. Br J Clin Pharmacol. 2014 Feb 18. doi: 10.1111/bcp.12355. [Epub ahead of print]. Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective…

General

Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma. Dimopoulos MA et al. Leukemia. 2014 Feb 5. doi: 10.1038/leu.2014.60. [Epub ahead of print]. European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma. Engelhardt M et al. Haematologica. 2014 Feb;99(2):232-42. doi: 10.3324/haematol.2013.099358.…

Diagnostic tests and prognostic indicators

PET/CT studies of multiple myeloma using 18 F-FDG and 18 F-NaF: comparison of distribution patterns and tracers’ pharmacokinetics. Sachpekidis C et al. Eur J Nucl Med Mol Imaging. 2014 Feb 22. [Epub ahead of print]. Inter-laboratory comparison of Beta-2 microglobulin and albumin methods: impact of assay variation on multiple myeloma staging. Fedele PL et al. Pathology. 2014…