Category Archives: Management of Myeloma

Biology and genetics

Outcome of Patients with Multiple Myeloma and CKS1B Gene Amplification after Autologous Hematopoietic Stem Cell Transplantation. Bock F et al. Biol Blood Marrow Transplant. 2016 Sep 13. pii: S1083-8791(16)30329-9. doi: 10.1016/j.bbmt.2016.09.003. [Epub ahead of print]. Outcomes in patients with multiple myeloma with TP53 deletion after autologous hematopoietic stem cell transplant. Gaballa S et al. Am J Hematol. 2016 Oct;91(10):E442-7. doi: 10.1002/ajh.24487. Epub 2016 Sep 3.…

Biology and genetics

Genomic complexity of multiple myeloma and its clinical implications. Manier S et al. Nat Rev Clin Oncol. 2016 Aug 17. doi: 10.1038/nrclinonc.2016.122. [Epub ahead of print]. Baseline characteristics, chromosomal alterations and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma. Merz M et al. Am J Hematol. 2016 Aug 10. doi: 10.1002/ajh.24533. [Epub ahead of print]. Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple…

Biology and genetics

Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Colombo M et al. Oncotarget. 2016 Jul 24. doi: 10.18632/oncotarget.10820. [Epub ahead of print]. HLA polymorphism and risk of multiple myeloma. Beksac M et al. Leukemia. 2016 Jul 27. doi: 10.1038/leu.2016.199. [Epub ahead of print]. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Ito T et…

Biology and genetics

HIF-1α and rapamycin act as genosuppressant in multiple myeloma cells upon genotoxic stress. Coudre C et al. Cell Cycle. 2016 Jun 24:0. [Epub ahead of print]. CA-125 secreting IgG kappa Multiple Myeloma (MM). Boota M et al. Am J Hematol. 2016 Jun 24. doi: 10.1002/ajh.24456. [Epub ahead of print]. To B(ortezomib) or Not to B: The Stroma’s the Thing. Krem MM et al. J Pathol. 2016 Jun 24.…

Biology and genetics

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease. Fu J et al. J Clin Invest. 2016 Apr 4. pii: 80276. doi: 10.1172/JCI80276. [Epub ahead of print]. Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients. Bieghs L et al. PLoS One. 2016 Apr 25;11(4):e0154256. doi: 10.1371/journal.pone.0154256. eCollection 2016. Assessment of tumoral plasma cells in apheresis products for autologous stem…

Biology and genetics

Multiple myeloma cancer stem cells. Gao M et al. Oncotarget. 2016 Mar 17. doi: 10.18632/oncotarget.8154. [Epub ahead of print]. Myeloma cell dynamics in response to treatment supports a model of hierarchical differentiation and clonal evolution. Tang M et al. Clin Cancer Res. 2016 Mar 22. pii: clincanres.2793.2015. [Epub ahead of print]. Multiple myeloma in the marrow: pathogenesis and treatments. Fairfield H et al. Ann N Y…

Biology and genetics

USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells. Jin Y et al. Biomed Pharmacother. 2016 Mar;78:264-71. doi: 10.1016/j.biopha.2016.01.012. Epub 2016 Feb 2. Carfilzomib-induced cardiotoxicity mitigated by dexrazoxane through inhibition of hypertrophic gene expression and oxidative stress in rats. Al-Harbi NO et al. Toxicol Mech Methods. 2016 Feb 21:1-7. [Epub ahead of print]. Distinct lncRNA transcriptional fingerprints characterize progressive stages…

Biology and genetics

Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma. Johnson DC et al. Nat Commun. 2016 Jan 8;7:10290. doi: 10.1038/ncomms10290. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Zhang Z et al. Oncotarget. 2016 Jan 22. doi: 10.18632/oncotarget.6974. [Epub ahead of print]. Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells. Bartee…