Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma. Weinhold N et al. Haematologica. 2015 Nov 26. pii: haematol.2015.136929. [Epub ahead of print]. Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Dykstra KM et al. Oncotarget. 2015 Nov 22. doi: 10.18632/oncotarget.6365. [Epub ahead of print]. The role of circulating miRNAs in multiple myeloma.…
Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. Ludwig C et al. Blood Cancer J. 2015 Oct 16;5:e359. doi: 10.1038/bcj.2015.85. Impact of cytogenetic classification on outcomes following early high dose therapy in multiple myeloma. Kaufman GP et al. Leukemia. 2015 Oct 21. doi: 10.1038/leu.2015.287. [Epub ahead of print]. Insight into human…
Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma. Wong KY et al. Mol Cancer. 2015 Sep 26;14(1):175. 3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma. de la Puente P et al. Biomaterials. 2015 Sep 12;73:70-84. doi: 10.1016/j.biomaterials.2015.09.017. [Epub ahead of print] Transcriptional dysregulation of the deleted in colorectal carcinoma gene in multiple…
A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias. Lionetti M et al. Oncotarget. 2015 Jul 20. [Epub ahead of print]. The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Follin-Arbelet V et al. Sci Rep. 2015 Aug 26;5:13001. doi: 10.1038/srep13001. Notch signaling deregulation in multiple myeloma: A rational molecular target. Colombo M et…
Implementation of genome-wide complex trait analysis to quantify the heritability in multiple myeloma. Mitchell JS et al. Sci Rep. 2015 Jul 24;5:12473. doi: 10.1038/srep12473. MB4-2 breakpoint in MMSET combined with del(17p) defines a subset of t(4;14) multiple myeloma with very poor prognosis. Lazareth A et al. Haematologica. 2015 Jul 23. pii: haematol.2015.127001. [Epub ahead of print]. Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of…
Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma. Zang M et al. Cancer Lett. 2015 Jun 23. pii: S0304-3835(15)00403-6. doi: 10.1016/j.canlet.2015.06.011. [Epub ahead of print]. Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Kandela I et al. Elife. 2015 Jun 25;4. doi: 10.7554/eLife.07072. KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Riz I et…
Lenalidomide augments actin remodelling and lowers NK cell activation thresholds. Lagrue K et al. Blood. 2015 May 22. pii: blood-2015-01-625004. [Epub ahead of print]. CD229 is expressed on the surface of plasma cells carrying an aberrant phenotype and chemotherapy-resistant precursor cells in Multiple Myeloma. Yousef S et al. Hum Vaccin Immunother. 2015 May 22:0. [Epub ahead of print]. MicroC3: an ex vivo…
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma. Walker BA et al. Nat Commun. 2015 Apr 23;6:6997. doi: 10.1038/ncomms7997. Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1. Fujiwara S et al. Exp Hematol Oncol. 2015 Apr 21;4:12. doi: 10.1186/s40164-015-0008-z. eCollection 2015. Dutcher bodies in multiple myeloma are highly associated with translocation t(4;14) and IgA…
Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Kikuchi S et al. Leukemia. 2015 Mar 24. doi: 10.1038/leu.2015.83. [Epub ahead of print]. Structure-activity relationships of benzhydrol derivatives based on 1′-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-κB pathway. Misawa T et al. Bioorg Med Chem. 2015 Mar 7. pii: S0968-0896(15)00143-1. doi:…
Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells. Anastasiadou E et al. Int J Cancer. 2015 Feb 20. doi: 10.1002/ijc.29489. [Epub ahead of print]. BCL2L11/Bim as a dual-agent regulating autophagy and apoptosis in drug resistance. Dai Y et al. Autophagy. 2015 Feb 20:0. [Epub ahead of print]. Hyaluronan synthase 1: a mysterious enzyme with unexpected functions. Siiskonen H et…