Biology and genetics

Pomalidomide plus low-dose dexamethasone in multiple myeloma with deletion 17p and/or translocation (4;14): IFM 2010-02. Leleu X et al. Blood. 2015 Jan 9. pii: blood-2014-11-612069. [Epub ahead of print]. The predominant myeloma clone at diagnosis, CDR3 defined, is constantly detectable across all stages of disease evolution. Puig N et al. Leukemia. 2015 Jan 8. doi: 10.1038/leu.2015.7. [Epub ahead of print]. Combined immune checkpoint protein blockade…

Biology and genetics

Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups. Gomez-Bougie P et al. Cancer Biol Ther. 2014 Dec 17:0. [Epub ahead of print]. Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Nijhof IS et al. Haematologica. 2014 Dec 15. pii: haematol.2014.117531. [Epub ahead of print]. Doxorubicin Overcomes Resistance…

Biology and genetics

Ex Vivo-expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients. Szmania S et al. J Immunother. 2014 Nov 20. [Epub ahead of print]. Establishment of a Murine Graft-versus-Myeloma Model Using Allogeneic Stem Cell Transplantation. Binsfeld M et al. PLoS One. 2014 Nov 21;9(11):e113764. doi: 10.1371/journal.pone.0113764. eCollection 2014. Exploration for the multi-effect of cardamom in’s resistance to multiple myeloma. Zhihua…

Biology and genetics

Immune impairments in multiple myeloma bone marrow mesenchymal stromal cells. André T et al. Cancer Immunol Immunother. 2014 Oct 24. [Epub ahead of print]. Inhibition of Akt-signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy. van der Waart AB et al. Blood. 2014 Oct 21. pii: blood-2014-05-578583. [Epub ahead of print]. Global…

Biology and genetics

Deazaneplanocin A Is a Promising Drug to Kill Multiple Myeloma Cells in Their Niche. Gaudichon J et al. PLoS One. 2014 Sep 25;9(9):e107009. doi: 10.1371/journal.pone.0107009. eCollection 2014. HIF-1α inhibition blocks the cross talk between multiple myeloma plasma cells and tumor microenvironment. Borsi E et al. Exp Cell Res. 2014 Sep 25. pii: S0014-4827(14)00423-6. doi: 10.1016/j.yexcr.2014.09.018.…

Biology and genetics

Pro-apoptotic effect of an anti-CD37 scFv-Fc fusion protein, in combination with the anti-CD20 antibody, ofatumumab, on tumour cells from B-cell malignancies. Smolewski P et al. Eur J Cancer. 2014 Aug 18. pii: S0959-8049(14)00873-9. doi: 10.1016/j.ejca.2014.07.021. [Epub ahead of print]. Cell membrane associated free kappa light chains are found on a subset of tonsil and in…

Biology and genetics

Proteasome function is required for platelet production. Shi DS et al. J Clin Invest. 2014 Jul 25. pii: 75247. doi: 10.1172/JCI75247. [Epub ahead of print]. Overexpression of CYR61/CCN1 in the multiple myeloma microenvironment is associated with superior survival and prevention of bone disease. Johnson SK et al. Blood. 2014 Jul 24. pii: blood-2014-02-555813. [Epub ahead…

Biology and genetics

A Novel Functional Role for MMSET in RNA Processing Based on the Link Between the REIIBP Isoform and Its Interaction with the SMN Complex. Mirabella F et al. PLoS One. 2014 Jun 12;9(6):e99493. doi: 10.1371/journal.pone.0099493. eCollection 2014. MicroRNA expression patterns in medullary and extramedullary plasmacytoma. Lin JJ et al. Blood Cancer J. 2014 Jun 27;4:e223.…

Biology and genetics

Microenvironment and multiple myeloma spread. Ribatti D et al. Thromb Res. 2014 May;133 Suppl 2:S102-6. doi: 10.1016/S0049-3848(14)50017-5. The role of bone morphogenetic proteins in myeloma cell survival. Holien T et al. Cytokine Growth Factor Rev. 2014 May 9. pii: S1359-6101(14)00042-2. doi: 10.1016/j.cytogfr.2014.04.009. [Epub ahead of print]. Anacardic acid induces cell apoptosis associated with induction of…

Biology and genetics

Jumping translocations and high-risk myeloma. Morgan GJ et al. Blood. 2014 Apr 17;123(16):2442-3. doi: 10.1182/blood-2014-02-555755. NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis. Ni H et al. PLoS One. 2014 Apr 22;9(4):e95846. doi: 10.1371/journal.pone.0095846. eCollection 2014. Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple…