Current treatments

Efficacy and Safety of Bortezomib Maintenance in Patients with Newly Diagnosed Multiple Myeloma: A Meta-Analysis. Sun CY et al. Biosci Rep. 2017 Jul 13. pii: BSR20170304. doi: 10.1042/BSR20170304. [Epub ahead of print]. Targeting complete response with upfront bortezomib consolidation versus observation after the achievement of complete response following autologous transplantation for multiple myeloma(TUBA study). Nakasone H et al. Hematol Oncol. 2017 Jul 6.…

Complications of myeloma and its treatments

Immunoglobulin A nephropathy in a patient with IgG kappa light-chain myeloma. Chandra A et al. Saudi J Kidney Dis Transpl. 2017 Jul-Aug;28(4):937-941. Priapism with penile gangrene: An unusual presentation of multiple myeloma. Panwar VK et al. Indian J Urol. 2017 Jul-Sep;33(3):251-252. doi: 10.4103/iju.IJU_41_17. Increased corneal densitometry as a subclinical corneal change associated with multiple myeloma. Busch C et al. Eye (Lond). 2017 Jul 14. doi: 10.1038/eye.2017.132. [Epub…

Biology and genetics

The first-in-class alkylating HDAC inhibitor EDO-S101 is highly synergistic with proteasome inhibition against multiple myeloma through activation of multiple pathways. Besse L et al. Blood Cancer J. 2017 Jul 28;7(7):e589. doi: 10.1038/bcj.2017.69. A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo. Hipp S et al. Leukemia. 2017 Jul 28. doi: 10.1038/leu.2017.219. [Epub ahead of print].…

Diagnostic techniques and prognostic indicators

Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests. Heaney JLJ et al. Br J Haematol. 2017 Jun 1. doi: 10.1111/bjh.14753. [Epub ahead of print]. Circulating adiponectin levels differ between patients with multiple myeloma and its precursor disease. Hofmann JN et al. Obesity (Silver Spring). 2017 Jun 11. doi: 10.1002/oby.21894. [Epub ahead of print]. Diffusion-weighted whole-body MRI for…

Related conditions

Daratumumab yields rapid and deep hematologic responses in patients with heavily pretreated AL amyloidosis. Kaufman GP et al. Blood. 2017 Jun 14. pii: blood-2017-01-763599. doi: 10.1182/blood-2017-01-763599. [Epub ahead of print]. The role of frontline autologous stem cell transplantation for primary plasma cell leukemia: a retrospective multicenter study (KMM160). Jung SH et al. Oncotarget. 2017 Jun 16. doi: 10.18632/oncotarget.18535. [Epub ahead of…

Emerging treatments

MEK inhibitors in oncology: a patent review (2015-Present). Mahapatra DK et al. Expert Opin Ther Pat. 2017 Jun 19:1-20. doi: 10.1080/13543776.2017.1339688. [Epub ahead of print]. Elotuzumab as a novel anti-myeloma immunotherapy. Radhakrishnan SV et al. Hum Vaccin Immunother. 2017 Jun 12:1-7. doi: 10.1080/21645515.2017.1327487. [Epub ahead of print]. Sending CAR T Cells After Multiple Myeloma. [No authors listed]. Cancer Discov. 2017 Jun 6. doi: 10.1158/2159-8290.CD-NB2017-088. [Epub…

Biology and genetics

A novel dual inhibitor of microtubule and Bruton’s Tyrosine Kinase inhibits survival of multiple myeloma and osteoclastogenesis. Pandey MK et al. Exp Hematol. 2017 Jun 21. pii: S0301-472X(17)30233-3. doi: 10.1016/j.exphem.2017.06.003. [Epub ahead of print]. Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma. Laganà A et al. Leukemia. 2017 Jun 23. doi: 10.1038/leu.2017.197. [Epub ahead of print]. Changes…

General

Living with the burden of relapse in multiple myeloma from the patient and physician perspective. Hulin C et al. Leuk Res. 2017 May 31;59:75-84. doi: 10.1016/j.leukres.2017.05.019. [Epub ahead of print]. The impact of comorbidity on mortality in multiple myeloma: a Danish nationwide population-based study. Gregersen H et al. Cancer Med. 2017 Jun 22. doi: 10.1002/cam4.1128. [Epub ahead of print]. Recent advances in understanding multiple myeloma.…

Supportive treatments

Comparison of the CELLEX™ and UVAR-XTS™ closed-system extracorporeal photopheresis devices in the treatment of chronic graft-versus-host disease. Whittle RM et al. J Clin Apher. 2017 Jun 13. doi: 10.1002/jca.21541. [Epub ahead of print]. Comparison of Operative Time with Conventional Fluoroscopy versus Spinal Neuronavigation in Instrumented Spinal Tumor Surgery. Miller JA et al. World Neurosurg. 2017 Jun 9. pii: S1878-8750(17)30908-7. doi: 10.1016/j.wneu.2017.06.016.…

Complications of myeloma and its treatments

Molecular mechanisms, current management and next generation therapy in myeloma bone disease. Heusschen R et al. Leuk Lymphoma. 2017 Jun 2:1-15. doi: 10.1080/10428194.2017.1323272. [Epub ahead of print]. An unusual presentation of multiple myeloma with unilateral sudden vision loss: A case report. Wu PW et al. Medicine (Baltimore). 2017 Jun;96(25):e7277. doi: 10.1097/MD.0000000000007277. Metabolic Syndrome in Long-Term Survivors of Hematopoietic Stem-Cell Transplantation. Ragbourne SC et al. Clin Lymphoma Myeloma Leuk. 2017 Jun;17(6):340-346.…