Biology and genetics

Genomic complexity of multiple myeloma and its clinical implications. Manier S et al. Nat Rev Clin Oncol. 2016 Aug 17. doi: 10.1038/nrclinonc.2016.122. [Epub ahead of print]. Baseline characteristics, chromosomal alterations and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma. Merz M et al. Am J Hematol. 2016 Aug 10. doi: 10.1002/ajh.24533. [Epub ahead of print]. Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple…

General

Is Maintenance Therapy for Everyone? Nooka AK et al. Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S139-44. doi: 10.1016/j.clml.2016.02.011. How to Think About Risk in Myeloma. Krishnan A. Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S135-8. doi: 10.1016/j.clml.2016.02.015. Clonal Evolution in Multiple Myeloma. Fakhri B et al. Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S130-4. doi: 10.1016/j.clml.2016.02.025. Concise review: Treatment of multiple myeloma in the very elderly: How do novel agents fit in? Kint N et al. J…

Supportive care

Cost-effectiveness analysis of low-molecular-weight heparin versus aspirin thromboprophylaxis in patients newly diagnosed with multiple myeloma. Chalayer E et al. Thromb Res. 2016 Aug 10;145:119-125. doi: 10.1016/j.thromres.2016.08.008. [Epub ahead of print]. Cryotherapy reduces oral mucositis and febrile episodes in myeloma patients treated with high-dose melphalan and autologous stem cell transplant: a prospective, randomized study. Marchesi F et al. Bone Marrow Transplant. 2016 Aug 15. doi:…

Complications of myeloma and its treatments

Chemotherapy treatment of multiple myeloma patients increases circulating levels of endothelial microvesicles. Hall J et al. Thromb Res. 2016 Aug 17;146:20-22. doi: 10.1016/j.thromres.2016.08.017. [Epub ahead of print]. Diarrhea in Multiple Myeloma: A Review of the Literature. Faiman B et al. Clin J Oncol Nurs. 2016 Aug 1;20(4):E100-5. doi: 10.1188/16.CJON.E100-E105. Secondary malignancies in patients with multiple myeloma, Waldenström macroglobulinemia and monoclonal gammopathy of undetermined significance. Castillo…

Current treatments

The impact of induction regimen on transplant outcome in newly diagnosed multiple myeloma in the era of novel agents. Chakraborty R et al. Bone Marrow Transplant. 2016 Aug 22. doi: 10.1038/bmt.2016.214. [Epub ahead of print]. Plerixafor for autologous stem-cell mobilization and transplantation for patients in Ontario. Kouroukis CT et al. Curr Oncol. 2016 Aug;23(4):e409-30. doi: 10.3747/co.23.3137. Epub 2016 Aug 12. Mobilization of autologous…

Diagnostic tests and prognostic indicators

Clinicopathological significance of p15 promoter hypermethylation in multiple myeloma: a meta-analysis. Wei B et al. Onco Targets Ther. 2016 Jul 1;9:4015-22. doi: 10.2147/OTT.S102733. eCollection 2016. RGS1 expression is associated with poor prognosis in multiple myeloma. Roh J et al. J Clin Pathol. 2016 Jul 21. pii: jclinpath-2016-203713. doi: 10.1136/jclinpath-2016-203713. [Epub ahead of print]. Diagnostic performances of M-protein tests according to the clinical presentations…

Related conditions

Rationale, application, and clinical qualification for NT-proBNP as a surrogate end point in pivotal clinical trials in patients with AL amyloidosis. Merlini G et al. Leukemia. 2016 Jul 15. doi: 10.1038/leu.2016.191. [Epub ahead of print]. Bridging the Divide: An Onco-Nephrologic Approach to the Monoclonal Gammopathies of Renal Significance. Hogan JJ et al. Clin J Am Soc Nephrol. 2016 Jul 14. pii:…

Biology and genetics

Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Colombo M et al. Oncotarget. 2016 Jul 24. doi: 10.18632/oncotarget.10820. [Epub ahead of print]. HLA polymorphism and risk of multiple myeloma. Beksac M et al. Leukemia. 2016 Jul 27. doi: 10.1038/leu.2016.199. [Epub ahead of print]. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Ito T et…

General

The role of proteasome inhibition in the treatment of malignant and non-malignant hematologic disorders. Citrin R et al. Expert Rev Hematol. 2016 Jul 22. [Epub ahead of print]. A new era of immune therapy in multiple myeloma. Tai YT et al. Blood. 2016 Jul 21;128(3):318-9. doi: 10.1182/blood-2016-06-719856. The efficacy and tolerability of pomalidomide in relapsed/refractory myeloma patients in a “real-world” study: the Royal Marsden…