Emerging treatments

Oral Ixazomib Maintenance Therapy in Multiple Myeloma. Offidani M et al. Expert Rev Anticancer Ther. 2015 Nov 20. [Epub ahead of print]. Effective use of panobinostat in combination with other active agents in myeloma in a novel 5-drug combination: Case Report and Interesting Observations. Rajan AM et al. Am J Hematol. 2015 Nov 17. doi: 10.1002/ajh.24244. [Epub ahead of print]. Efficacy and safety of…

Biology and genetics

Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma. Weinhold N et al. Haematologica. 2015 Nov 26. pii: haematol.2015.136929. [Epub ahead of print]. Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Dykstra KM et al. Oncotarget. 2015 Nov 22. doi: 10.18632/oncotarget.6365. [Epub ahead of print]. The role of circulating miRNAs in multiple myeloma.…

General

Targeting Cyclin-Dependent Kinases and Cell Cycle Progression in Human Cancers. Santo L et al. Semin Oncol. 2015 Dec;42(6):788-800. doi: 10.1053/j.seminoncol.2015.09.024. Epub 2015 Sep 24. Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma in Older Adults. Guerard EJ et al. Clin Geriatr Med. 2016 Feb;32(1):191-205. doi: 10.1016/j.cger.2015.08.012. Epub 2015 Oct 9. Multiple myeloma and physical activity: a scoping review. Smith L et al. BMJ Open. 2015 Nov 27;5(11):e009576.…

Complications of myeloma and its treatments

A Report of 134 Newly Diagnosed Multiple Myeloma Patients with Renal Impairment. Liu A et al. Acta Haematol. 2015 Nov 21;135(3):140-145. [Epub ahead of print]. CD4(+)CD25(+) cells in multiple myeloma related renal impairment. Huang H et al. Sci Rep. 2015 Nov 13;5:16565. doi: 10.1038/srep16565. Complications after surgery for metastatic humeral lesions. Janssen SJ et al. J Shoulder Elbow Surg. 2015 Nov 4. pii: S1058-2746(15)00446-2. doi: 10.1016/j.jse.2015.08.009. [Epub ahead…

Current treatments

Evaluation of low-dose thalidomide as induction and maintenance therapy in patients with multiple myeloma not eligible for stem cell transplantation. Aznab M et al. Asia Pac J Clin Oncol. 2015 Nov 4. doi: 10.1111/ajco.12418. [Epub ahead of print]. Phase 3 trial of three thalidomide-containing regimens in patients with newly diagnosed multiple myeloma not transplant-eligible. Hungria VT et al. Ann Hematol. 2015 Oct 30. [Epub ahead…

Diagnostic tests and prognostic indicators

Positron emission tomography-computed tomography in the diagnostic evaluation of smoldering multiple myeloma: identification of patients needing therapy. Siontis B et al. Blood Cancer J. 2015 Oct 23;5:e364. doi: 10.1038/bcj.2015.87. 18F-FDG PET/CT FOCAL, but not osteolytic, lesions predict the progression of smoldering myeloma to active disease. Zamagni E et al. Leukemia. 2015 Oct 22. doi: 10.1038/leu.2015.291. [Epub ahead of print]. MMSA-1 expression pattern in multiple myeloma and…

Related conditions

TCL1 expression patterns in Waldenström macroglobulinemia. Lemal R et al. Mod Pathol. 2015 Oct 23. doi: 10.1038/modpathol.2015.122. [Epub ahead of print]. Cast nephropathy: an extremely rare renal presentation of Waldenström’s macroglobulinaemia. Santos T et al. BMJ Case Rep. 2015 Oct 7;2015. pii: bcr2015211210. doi: 10.1136/bcr-2015-211210. Severe peripheral neuropathy following carfilzomib, rituximab, and dexamethasone for initial treatment of Waldenström’s macroglobulinemia. Alfaraj WA et…