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The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM.
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Notch signaling deregulation in multiple myeloma: A rational molecular target.
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GDF15 promotes osteoclast differentiation, inhibits osteoblast differentiation and high serum GDF15 levels are associated with multiple myeloma bone disease.
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Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma.
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The forkhead transcription factor FOXP1 represses human plasma cell differentiation.
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Blocking the ZZ domain of sequestosome 1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo.
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Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach.
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Detection of chromosome 13 (13q14) deletion among Sudanese patients with multiple myeloma using a molecular genetics fluorescent in situ hybridization technique (FISH).
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Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.
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Increased expression of metalloproteinase-2 and -9 (MMP-2, MMP-9), tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1, TIMP-2), and EMMPRIN (CD147) in multiple myeloma.
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Sphingosine kinase-1 protects multiple myeloma from apoptosis driven by cancer specific inhibition of RTKs.
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Targeting executioner procaspase-3 with the procaspase activating compound B-PAC-1 induces apoptosis inmultiple myeloma cells.
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Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma.
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Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma.
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Targeting the miR-221-222/PUMA/BAK/BAX pathway abrogates dexamethasone resistance in multiple myeloma.
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A unique aptamer-drug conjugate for targeted therapy of multiple myeloma.
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VR23: a quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin E-mediated centrosome amplification.
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A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function.
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Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim.
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Affinity-Enhanced TCR-Engineered T Cells Induce Antimyeloma Responses.
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Inhibiting MEK in MAPK pathway activated myeloma.
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Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma.
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Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance.
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FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.
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