Related conditions

Periorbital papules as a presenting sign in multiple myeloma with AL amyloidosis. Vilcassim FS et al. BMJ Case Rep. 2017 Feb 20;2017. pii: bcr2016219010. doi: 10.1136/bcr-2016-219010. Amyloidosis: A cancer-derived paraproteinemia and kidney involvement. Małyszko J et al. Adv Med Sci. 2017 Jan 30;62(1):31-38. doi: 10.1016/j.advms.2016.06.004. [Epub ahead of print]. Pure Red Cell Aplasia Associated with Monoclonal Gammopathy of Undetermined Significance and Literature Review.…

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Emerging treatments

Conditioning regimens for autologous haematopoietic stem cell transplantation – can natural killer cell therapy help? Snowden JA et al. Br J Haematol. 2017 Feb 17. doi: 10.1111/bjh.14565. [Epub ahead of print]. Phase I/II study of the novel proteasome inhibitor delanzomib (CEP-18770) for relapsed and refractory multiple myeloma. Vogl DT et al. Leuk Lymphoma. 2017 Jan 31:1-11. doi: 10.1080/10428194.2016.1263842. [Epub ahead of print].…

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Biology and genetics

Mutational landscape reflects the biological continuum of plasma cell dyscrasias. Rossi A et al. Blood Cancer J. 2017 Feb 24;7(2):e537. doi: 10.1038/bcj.2017.19. Ecto-5′ -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients – Data from the German Calciphylaxis Registry. Rothe H et al. PLoS One. 2017…

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General

Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population-based study. Howell D et al. Br J Haematol. 2017 Feb 1. doi: 10.1111/bjh.14513. [Epub ahead of print]. High-dose chemotherapy and autologous stem cell transplantation of patients with multiple myeloma in an outpatient setting. Lisenko K et al. BMC Cancer. 2017 Feb 22;17(1):151. doi: 10.1186/s12885-017-3137-4. Association between response rates…

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Supportive treatments

Real-life practices for preventing venous thromboembolism in multiple myeloma patients: a cohort study from the French health insurance database. Palmaro A et al. Pharmacoepidemiol Drug Saf. 2017 Feb 15. doi: 10.1002/pds.4180. [Epub ahead of print]. Associations of high-dose melphalan pharmacokinetics and outcomes in the setting of a randomized cryotherapy trial. Cho YK et al. Clin Pharmacol Ther. 2017 Feb 4. doi: 10.1002/cpt.644. [Epub…

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Complications of myeloma and its treatments

Renal failure in multiple myeloma: something new on the horizon. Offidani M et al. Br J Haematol. 2017 Feb 17. doi: 10.1111/bjh.14548. [Epub ahead of print]. Delphi-based study and analysis of key risk factors for invasive fungal infection in haematological patients. Vázquez L et al. Rev Esp Quimioter. 2017 Feb 14. pii: vazquez14feb2017. [Epub ahead of print]. Myelosuppression-sparing treatment of central nervous…

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Current treatments

Phase II study of bendamustine, bortezomib and dexamethasone (BBD) in the first-line treatment of patients with multiple myeloma who are not candidates for high dose chemotherapy. Berdeja JG et al. Br J Haematol. 2017 Feb 7. doi: 10.1111/bjh.14536. [Epub ahead of print]. Impact of induction treatment before autologous stem cell transplantation on long term outcome in patients with newly diagnosed multiple…

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Study shows no link between response rates and survival in myeloma

Results of a meta-regression analysis have shown that, contrary to popular opinion, there is no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and survival in newly diagnosed myeloma patients. Published recently in the European Journal of Haematology, the researchers explored the relationship between response to initial…

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New UK guidelines for managing the “late effects” of myeloma and its treatment

Myeloma UK together with the British Committee for Standards in Haematology (BCSH) and the United Kingdom Myeloma Forum (UKMF) have jointly published new guidelines for the screening and management of the late and long-term consequences of myeloma and its treatments. Published recently in the British Journal of Haematology, the guidelines highlight the key late effects…

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Diagnostic techniques and prognostic indicators

Recovery of polyclonal immunoglobulins one year after autologous stem cell transplantation as a long-term predictor marker of progression and survival in multiple myeloma. González-Calle V et al. Haematologica. 2017 Jan 25. pii: haematol.2016.158345. doi: 10.3324/haematol.2016.158345. [Epub ahead of print]. Capillary electrophoresis analysis of N-glycosylation changes of serum paraproteins in multiple myeloma. Kovacs Z et al. Electrophoresis. 2017 Jan 24. doi: 10.1002/elps.201700006. [Epub ahead…

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