Diagnostic tests and prognostic indicators

11C-PiB PET/CT in Nasopharyngeal Amyloidosis Associated with Multiple Myeloma. Ishimura M et al. Clin Nucl Med. 2014 Aug 19. [Epub ahead of print]. Absolute Lymphocyte Count Is Unrelated to Overall Survival in Newly Diagnosed Elderly Patients with Multiple Myeloma Treated with Immunomodulatory Drugs. Napolitano M et al. Leuk Lymphoma. 2014 Aug 20:1-10. [Epub ahead of…

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Emerging treatments

Oral therapy for multiple myeloma: ixazomib arriving soon.Moreau P. Blood. 2014 Aug 14;124(7):986-7. doi: 10.1182/blood-2014-06-581611.A multicenter, open-label phase II study of recombinant CPT (circularly permuted TRAIL) plus thalidomide in patients with relapsed and/or refractory multiple myeloma.Geng C et al. Am J Hematol. 2014 Aug 4. doi: 10.1002/ajh.23822. [Epub ahead of print].Novel AKT inhibitor afuresertib shows…

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Biology and genetics

Pro-apoptotic effect of an anti-CD37 scFv-Fc fusion protein, in combination with the anti-CD20 antibody, ofatumumab, on tumour cells from B-cell malignancies. Smolewski P et al. Eur J Cancer. 2014 Aug 18. pii: S0959-8049(14)00873-9. doi: 10.1016/j.ejca.2014.07.021. [Epub ahead of print]. Cell membrane associated free kappa light chains are found on a subset of tonsil and in…

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Supportive care

A Phase IB multicentre dose-determination study of BHQ880 in combination with anti-myeloma therapy and zoledronic acid in patients with relapsed or refractory multiple myeloma and prior skeletal-related events.Iyer SP et al. Br J Haematol. 2014 Aug 19. doi: 10.1111/bjh.13056. [Epub ahead of print].Effect of Clodronate Treatment on Risk of Fracture: A Systematic Review and Meta-analysis.Frediani…

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Complications of myeloma and its treatments

Subclinical Peripheral Neuropathy in Patients With Multiple Myeloma Before Chemotherapy Is Correlated With Decreased Fingertip Innervation Density. Kosturakis AK et al. J Clin Oncol. 2014 Aug 25. pii: JCO.2013.54.5418. [Epub ahead of print]. Hepatitis B virus reactivation in multiple myeloma patients receiving bortezomib-containing regimens followed by autologous stem cell transplantation. Li J et al. Leuk…

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Current treatments

Update of the GEM2005 trial comparing VMP/VTP as induction in elderly multiple myeloma patients: do we still need alkylators? Mateos MV et al. Blood. 2014 Aug 7. pii: blood-2014-05-573733. [Epub ahead of print]. Safety and Efficacy of Targeted-Dose Busulfan and Bortezomib as Conditioning Regimen for Patients with Relapsed Multiple Myeloma Undergoing a Second Autologous Blood…

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Guidelines for the diagnosis and management of multiple myeloma 2013 – presentation and diagnosis

These updated guidelines, produced by the British Committee for Standards in Haematology (BCSH) and the UK Myeloma Forum, summarise a national consensus of the haematological community involved in the diagnosis and management of myeloma patients. They should be read in conjunction with the BCSH Guidelines on the supportive care of myeloma patients. Bird et al.…

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Guidelines for supportive care in multiple myeloma 2011

These guidelines, produced by the British Committee for Standards in Haematology (BCSH) and the UK Myeloma Forum, summarise a national consensus of the haematological community involved in the supportive care of myeloma patients and should be read in conjunction with the BCSH Guidelines for the diagnosis and management of myeloma.