Biology and genetics

Proteasome function is required for platelet production. Shi DS et al. J Clin Invest. 2014 Jul 25. pii: 75247. doi: 10.1172/JCI75247. [Epub ahead of print]. Overexpression of CYR61/CCN1 in the multiple myeloma microenvironment is associated with superior survival and prevention of bone disease. Johnson SK et al. Blood. 2014 Jul 24. pii: blood-2014-02-555813. [Epub ahead…

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Complications of myeloma and its treatments

A Rare Concurrence: Nonischemic Cardiomyopathy and Multiple Myeloma Without Amyloidosis. Gupta T et al. Am J Med. 2014 Jul 21. pii: S0002-9343(14)00592-0. doi: 10.1016/j.amjmed.2014.07.012. [Epub ahead of print]. Incidence of Pneumocystis jiroveci Pneumonia among Groups at Risk in HIV-negative Patients. Fillatre P et al. Am J Med. 2014 Jul 21. pii: S0002-9343(14)00590-7. doi: 10.1016/j.amjmed.2014.07.010. [Epub…

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Current treatments

Bortezomib-thalidomide-based regimens improved clinical outcomes without increasing toxicity as induction treatment for untreated multiple myeloma: A meta-analysis of phase III randomized controlled trials. Huang H et al. Leuk Res. 2014 Jun 30. pii: S0145-2126(14)00188-X. doi: 10.1016/j.leukres.2014.06.009. [Epub ahead of print]. Long-term survival with cyclophosphamide, bortezomib and dexamethasone induction therapy in patients with newly diagnosed multiple…

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Related conditions

Gastrointestinal Amyloidosis and Multiple Myeloma. Alahdab F et al. J Gen Intern Med. 2014 Jun 4. [Epub ahead of print]. Auto-SCT improves survival in systemic light chain amyloidosis: a retrospective analysis with 14-year follow-up. Parmar S et al. Bone Marrow Transplant. 2014 Jun 2. doi: 10.1038/bmt.2014.115. [Epub ahead of print]. Epidemiology of Monoclonal Gammopathy of…

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General

Allogeneic Transplant in Multiple Myeloma: A Potential Renaissance in the Era of Novel Therapies? Richardson P. Biol Blood Marrow Transplant. 2014 Jun 20. pii: S1083-8791(14)00363-2. doi: 10.1016/j.bbmt.2014.06.013. [Epub ahead of print]. Bendamustine for the treatment of multiple myeloma in first-line and relapsed-refractory settings: a review of clinical trial data. Palumbo A et al. Leuk Lymphoma.…

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Diagnostic tests and prognostic indicators

Predicting multiple myeloma disease activity by analyzing natural calcium isotopic composition. Gordon GW et al. Leukemia. 2014 Jun 12. doi: 10.1038/leu.2014.193. [Epub ahead of print]. Identification of cereblon binding proteins and relationship with response and survival following pomalidomide and dexamethasone in multiple myeloma. Zhu YX et al. Blood. 2014 Jun 9. pii: blood-2014-02-557819. [Epub ahead…

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Emerging treatments

Phase 1 study of twice-weekly dosing of investigational oral proteasome inhibitor ixazomib in patients with relapsed and/or refractory multiple myeloma. Richardson PG et al. Blood. 2014 Jun 11. pii: blood-2014-01-548826. [Epub ahead of print]. A phase II trial of BAY 43-9006 (sorafenib) (NSC-724772) in patients with relapsing and resistant multiple myeloma: SWOG S0434. Srkalovic G…

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Biology and genetics

A Novel Functional Role for MMSET in RNA Processing Based on the Link Between the REIIBP Isoform and Its Interaction with the SMN Complex. Mirabella F et al. PLoS One. 2014 Jun 12;9(6):e99493. doi: 10.1371/journal.pone.0099493. eCollection 2014. MicroRNA expression patterns in medullary and extramedullary plasmacytoma. Lin JJ et al. Blood Cancer J. 2014 Jun 27;4:e223.…

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