Reducing serious infection in newly diagnosed myeloma patients by antibiotic prophylaxis: results from the TEAMM trial

Serious infection is one of the largest contributors to early mortality in myeloma. The use of antibiotic prophylaxis for newly diagnosed patients starting treatment offers an opportunity to tackle this early complication however the potential for antibiotic resistance, side effects and healthcare associated infections needs to be carefully considered. Last month Prof Mark Drayson, Consultant…

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New international guidelines recommend the use of whole-body imaging in monoclonal plasma cell disorders

New recommendations from the International Myeloma Working Group (IMWG) on the use of imaging methods in monoclonal plasma cell disorders were recently published in The Lancet Oncology. (1) Overall, the guidelines recommend that more sensitive imaging techniques, such as whole-body CT and MRI, be introduced generally into clinical practices for the diagnosis and management of…

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NICE to consider lenalidomide maintenance treatment for myeloma patients post high dose therapy and stem cell transplantation

Lenalidomide (Revlimid®) maintenance for myeloma patients who have undergone high dose therapy and stem cell transplantation (HDT-SCT) will be considered for use on the NHS by The National Institute for Health and Care Excellence (NICE) later this year. This announcement comes after updated advice from the manufacturer Celgene and follows publication of data from the Myeloma XI clinical…

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Daratumumab combinations are effective for the treatment of newly diagnosed myeloma.

Results from two phase III clinical trials (MAIA and CASSOPIEA) evaluating daratumumab (Darzalex®) combinations for the treatment of newly diagnosed myeloma patients have been recently published. The data provide evidence to support the use of daratumumab for the treatment of newly diagnosed myeloma patients whether they are eligible for high dose therapy and stem cell…

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Daratumumab combination treatment approved for NHS use in England and Wales through the Cancer Drugs Fund

This new treatment combination is being made available via the CDF on the NHS for the first time following a recommendation by the National Institute of Health and Care Excellence (NICE). This decision follows an earlier draft negative decision by NICE in July last year. Daratumumab, which is produced by the pharmaceutical company Janssen, belongs to a…

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