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Peripheral neuropathy is the most common neurological complication in surviving myeloma patients. Effects can be permanent and require ongoing symptom management with appropriate neuropathic pain treatments. Potentially neurotoxic treatments should be used cautiously in patients with existing neuropathy, with close monitoring using appropriate assessment tools.

Neuropathy can also be a complication of diabetes, renal impairment and vitamin deficiency. Screening is recommended for patients with neuropathy with the following tests: thyroid function, vitamin B12 level, diabetes and renal function. Specialist neurological assessment can help identify the cause for some patients.