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P-BCMA-101 Clinical Data Presented at CAR-TCR Summit

Poseida Provides Update on Phase 1 Study of P-BCMA-101 CAR-T Stem Cell Memory Product in Patients with Relapsed/Refractory Multiple Myeloma Poseida Therapeutics Inc. – a clinical-stage biotechnology company translating best-in-class gene engineering technologies into lifesaving cell therapies – announced data results from the first eleven patients treated in its ongoing Phase 1 study of its…

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Myeloma UK is helping to Make Blood Cancer Visible this September

Myeloma UK is helping to Make Blood Cancer Visible in September. The campaign, in partnership with Janssen Oncology and eight patient organisations, marks Blood Cancer Awareness Month. It will feature a public art installation, which will help visitors to understand the experiences of people affected by blood cancer.   The installation is made up of…

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Darzalex gains EU approval for new frontline combination treatment

Janssen has announced EU approval of Darzalex (daratumumab) for use alongside Takeda’s Velcade (bortezomib), melphalan and prednisone (VMP) for newly diagnosed myeloma patients who are ineligible for high-dose chemotherapy and autologous stem cell transplant (ASCT). The approval is based on results of the ALCYONE clinical trial which showed that adding Darzalex to VMP reduces the risk of…

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Prophylactic antibiotic combination reduces incidence of infection following ASCT

Results from a retrospective study have shown that prophylactic treatment with doxycycline and ciprofloxacin reduces the incidence of infection in myeloma patients following an autologous stem cell transplant (ASCT), when compared to treatment with ciprofloxacin alone. Published in Supportive Cancer Care, the results show that 53% of patients receiving ciprofloxacin alone developed neutropenic fever compared…

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EMA issues second negative recommendation for plitidepsin combination

The European Medicines Agency (EMA) has issued a second negative recommendation for plitidepsin (Aplidin®) in combination with dexamethasone for the treatment of relapsed and refractory myeloma. The application to authorise this treatment combination was re-examined by the EMA after receiving an initial negative recommendation in December 2017. This decision was based upon data from the…

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Results from Phase II vaccine trial announced

The biopharmaceutical company, SELLAS Life Sciences, has presented results from its Phase II galinpepimut-S trial at the 44th Annual European Society for Blood and Marrow Transplantation (EBMT) meeting. Galinpepimut-S is a peptide vaccine that targets WT1, a protein expressed on the surface of myeloma cells, and stimulates a CD4+ and CD8+ immune response. The trial…

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Ixazomib combination demonstrates efficacy in relapsed and refractory myeloma patients

Results from a Phase II study, recently published in Leukaemia, show that the oral combination of ixazomib (Ninlaro®), pomalidomide (Imnovid®) and dexamethasone is effective in relapsed and refractory myeloma patients. All patients in this study were refractory to lenalidomide (Revlimid®). 48% of patients who received the recommended dose of ixazomib (4mg) achieved a partial response or…

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Pomalidomide combination shows efficacy in relapsed and refractory myeloma patients with renal impairment

Published in the Journal of Clinical Oncology, results from the Phase II trial, MM-013 show that pomalidomide (Imnovid®) in combination with low-dose dexamethasone is effective in relapsed and refractory patients with renal impairment. There were 3 cohorts in this trial; patients with moderate renal impairment (A), severe renal impairment (B) and severe impairment requiring haemodialysis…

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