Immunotherapy is an umbrella term that describes the different treatments which work by harnessing the immune system to attack cancer cells. Different antigens present at high levels on myeloma cells are targeted during immunotherapy, including BMCA, CD38 and CS1. More recently, new targets have been exploited such as GPRC5D and FCHR5.

Immunotherapy has been used with great success in many cancers. In this video, Dr Martin Kaiser explains what immunotherapy drugs are, how they work and the types of immunotherapies that are currently used in myeloma.

In summary the main types of immunotherapies now being investigated for the treatment of myeloma are:

• Next generation immunomodulatory drugs
• Monoclonal antibody drugs
• Antibody drug conjugates
• Bispecific antibodies
• CAR-T cell treatments