MNLP – Module 2 – Final assessment

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Question 1 of 20

1. Question
1 point(s)
Plasma cells develop from
- A. Basophils
- B. T lymphocytes
- C. B lymphocytes
- D. Dendritic cells
- E. Natural killer cells
Correct

Incorrect
Question 2 of 20

2. Question
1 point(s)
Which of the following statements about plasma cells is true?
- A. Are only found in myeloma patients
- B. Are produced by antigen-independent differentiation
- C. Are originally derived from myeloid stem cells
- D. Are the major source of antibody in the body
- E. Are short-lived in the bone marrow
Correct

Incorrect
Question 3 of 20

3. Question
1 point(s)
Immunoglobulins are composed of:
- A. One heavy chain and one light chain
- B. Two heavy chains and one light chain
- C. One heavy chain and two light chains
- D. Two heavy chains and two light chains
Correct

Incorrect
Question 4 of 20

4. Question
1 point(s)
How many major classes of immunoglobulins are there?
- A. 1
- B. 2
- C. 3
- D. 4
- E. 5
Correct

Incorrect
Question 5 of 20

5. Question
1 point(s)
IgG immunoglobulin
- A. Is the most abundant immunoglobulin in the blood
- B. Activates the complement system
- C. Exists as a dimer
- D. Protects mucosal surfaces
- E. Is an important component of the allergic reaction
Correct

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Question 6 of 20

6. Question
1 point(s)
Approximately how many patients have ‘light chain’ or ‘Bence Jones’ myeloma?
- A. 2%
- B. 5%
- C. 10%
- D. 20%
- E. 30%
Correct

Incorrect
Question 7 of 20

7. Question
1 point(s)
The second most common subtype of myeloma is:
- A. IgA
- B. IgD
- C. IgE
- D. IgG
- E. IgM
Correct

Incorrect
Question 8 of 20

8. Question
1 point(s)
Cytogenetics is concerned with the study of what?
- A. Inherited genetic traits
- B. Structure of the chromosomes
- C. Mutations in the DNA sequence
- D. Genes controlling cell growth and programmed cell death
Correct

Incorrect
Question 9 of 20

9. Question
1 point(s)
Which of the following statements is not true?
- A. Translocations can be identified using FISH analysis
- B. Translocations are not found in normal plasma cells
- C. Certain translocations correlate directly with prognosis
- D. Translocations are inherited
- E. The most frequent translocation involves chromosome 14
Correct

Incorrect
Question 10 of 20

10. Question
1 point(s)
What % of myeloma patients are found to have an abnormality of chromosome 13?
- A. 5%
- B. 10%
- C. 25%
- D. 45%
- E. 65%
Correct

Incorrect
Question 11 of 20

11. Question
1 point(s)
NFkB is a
- A. Pro-apoptotic factor
- B. Anti-apoptotic factor
- C. Transcription factor
- D. Cell cycle regulator
- E. Adhesion molecule
Correct

Incorrect
Question 12 of 20

12. Question
1 point(s)
When a myeloma cell is stimulated by IL-6 produced by an osteoblast, this represents
- A. Autocrine stimulation
- B. Paracrine stimulation
- C. Exocrine stimulation
- D. Endocrine stimulation
Correct

Incorrect

Question 13 of 20

13. Question

5 point(s)

Can you match the correct description to the words below?

Drag and drop your answers

Sort elements

Pluripotent stem cell
Chromosome
Antigen
Paraprotein
Immunoglobulins

Cells with the potential to differentiate into a variety of cells

Structures within cells in which the DNA is packaged

A substance recognised by the body as foreign which induces an immune response

A monoclonal immunoglobulin produced by myeloma cells

Proteins in blood that are produced by cells of the immune system called plasma cells

Correct

Incorrect

Question 14 of 20

14. Question
1 point(s)
Can you match the correct term in the sentence?

Studies have shown that genetic mutations acquired – X – are responsible for the development of malignant myeloma clones
- At the pluripotent stem cell level
- At the lymphoid stem cell level
- During B-cell development
- In long-lived plasma cells
Correct

Incorrect
Question 15 of 20

15. Question
1 point(s)
Can you match the correct term in the sentence below?

Ras is a – X –
- Tumour suppressor
- Proto-oncogene
- Regulator of programmed cell death
- Cyclin-dependent kinase inhibitor
- Epigenetic modifier
Correct

Incorrect
Question 16 of 20

16. Question
1 point(s)
A translocation identified in myeloma is written as t (14:16) (q32; q21)

Fill in the words broke, rejoined and wrong to describe what is happening
- Chromosome 14 at the point designated q32 and chromosome 16 at q21, and then the parts to the chromosome
Correct

Incorrect
Question 17 of 20

17. Question
1 point(s)
Assertion: Cytogenetic abnormalities are frequent in myeloma

BECAUSE

Reason: Inherited genes increase the risk of developing myeloma
- A. True True – reason correctly explains assertion
- B. True True – both statements are true but the reason does not explain the assertion
- C. True False
- D. False True
- E. False False
Correct

Incorrect
Question 18 of 20

18. Question
1 point(s)
Assertion: The two most frequent abnormalities involve abnormalities in chromosomes 13 and 14

BECAUSE

Reason: Chromosomes 13 and 14 are inherently unstable in plasma cells
- A. True True – reason correctly explains assertion
- B. True True – both statements are true but the reason does not explain the assertion
- C. True False
- D. False True
- E. False False
Correct

Incorrect
Question 19 of 20

19. Question
1 point(s)
Paraproteins are different to normal antibodies because they can only identify viruses but not bacteria
- A. True
- B. False
Correct

Incorrect
Question 20 of 20

20. Question
1 point(s)
The Freelite test is particularly useful for diagnosis patients with oligo-secretory myeloma
- A. True
- B. False
Correct

Incorrect

MNLP – Module 2 – Final assessment