MNLP – Module 3 – Final assessment

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Question 1 of 20

1. Question
1 point(s)
Presenting symptoms and complications of myeloma can include all of the following, except
- A. Bone pain
- B. Joint pain
- C. Spinal cord compression
- D. Fatigue
- E. Weight loss
Correct

Incorrect
Question 2 of 20

2. Question
1 point(s)
Overall, approximately what percentage of myeloma patients will develop skeletal abnormalities at some point during the course of their disease?
- A. 20%
- B. 40%
- C. 60%
- D. 80%
- E. 100%
Correct

Incorrect
Question 3 of 20

3. Question
1 point(s)
Which of the following tests is not best performed on bone marrow samples
- A. Electrophoresis
- B. Karyotyping
- C. Fluorescence in situ hybridisation (FISH)
- D. Plasma cell labelling index
- E. Immunophenotyping
Correct

Incorrect
Question 4 of 20

4. Question
1 point(s)
The following imaging techniques are used to diagnose and monitor myeloma except
- A. Radiological skeletal survey
- B. Computed tomography (CT)
- C. Bone scan
- D. Positron emission tomography (PET)
- E. Magnetic resonance imaging (MRI)
Correct

Incorrect
Question 5 of 20

5. Question
1 point(s)
The most common cause of kidney damage in myeloma patients is due to
- A. Hypertension
- B. Diabetes
- C. Glomerulonephritis
- D. Cast nephropathy
- E. Haemolytic uremic syndrome
Correct

Incorrect
Question 6 of 20

6. Question
1 point(s)
Signs and symptoms of hypercalcaemia include
- A. Polymyalgia
- B. Bone pain
- C. Shortness of breath
- D. Cardiac arrhythmia
- E. Numbness
Correct

Incorrect
Question 7 of 20

7. Question
1 point(s)
Myeloma-related end organ damage includes all of the following except
- A. Hypercalcaemia
- B. Renal impairment
- C. Anaemia
- D. Lytic bone lesions
- E. Peripheral neuropathy
Correct

Incorrect
Question 8 of 20

8. Question
1 point(s)
The erythrocyte sedimentation rate (ESR) can be a useful surrogate marker for
- A. Paraprotein and immunoglobulin concentration
- B. Red blood cell count
- C. Haemoglobin level
- D. Plasma viscosity
- E. Kidney function
Correct

Incorrect
Question 9 of 20

9. Question
1 point(s)
Which of the following is the most sensitive type of electrophoresis for detecting paraprotein?
- A. Serum protein electrophoresis (SPEP)
- B. Urine protein electrophoresis (UPEP)
- C. Immunoelectrophoresis (IE)
- D. Immunofixation electrophoresis (IFE)
- E. Polyacrylamide gel electrophoresis (PAGE)
Correct

Incorrect
Question 10 of 20

10. Question
1 point(s)
Which of the following measurements is no longer a specific requirement in the updated 2014 International Myeloma Working Group (IMWG) guidelines for the diagnosis of myeloma?
- A. Bone marrow plasma cell percentage
- B. Paraprotein
- C. Involved:uninvolved serum free light chain ratio
- D. Lytic bone lesions
- E. Haemoglobin
Correct

Incorrect
Question 11 of 20

11. Question
1 point(s)
The presence of AL amyloidosis can be demonstrated using
- A. Immunophenotyping
- B. Cytogenetic analysis
- C. Tissue biopsy
- D. Fluorescence in situ hybridisation (FISH)
- E. Plasma cell labelling index
Correct

Incorrect
Question 12 of 20

12. Question
1 point(s)
Monoclonal gammopathy of undetermined significance (MGUS) is defined by the following criteria except
- A. Bone marrow plasma cell > 10%
- B. Bone marrow plasma cell < 10%
- C. Serum paraprotein < 30g/L
- D. No bone lesions
- E. No anaemia
Correct

Incorrect

Question 13 of 20

13. Question

4 point(s)

13. Match the definition with the correct answer

Sort elements

Full blood count
Platelet count
WBC differential
Haemoglobin level

a) Yields the absolute number of whole blood cells in the blood sample

b) Yields the absolute number of platelets in the blood sample

c) Gives the numbers of different types of white blood cells

d) Assesses the degree of anaemia

Correct

Incorrect

Question 14 of 20

14. Question
2 point(s)
Which statement below describes osteoclasts and osteoblasts
Sort elements
- Osteoclasts
- Osteoblasts
- Bone cells responsible for bone breakdown
- Bone cells responsible for bone formation
Correct

Incorrect
Question 15 of 20

15. Question
1 point(s)
Can you match the correct term to the sentence below?

A solitary extramedullary plasmacytoma is defined as:
- A. A single mass (tumour) of monoclonal plasma cells existing within the bone
- B. A single mass (tumour) of monoclonal plasma cells existing outside of the bone
Correct

Incorrect
Question 16 of 20

16. Question
1 point(s)
Assertion: Myeloma patients are at a reduced risk of infection than normal healthy individuals

BECAUSE

Reason: Myeloma is a malignancy of plasma cells
- A. True True – reason correctly explains assertion
- B. True True – both statements are true but the reason does not explain the assertion
- C. True False
- D. False True
- E. False False
Correct

Incorrect
Question 17 of 20

17. Question
1 point(s)
Assertion: Spinal cord compression is a potentially serious complication of myeloma bone disease

BECAUSE

Reason: Myeloma can cause severe damage to bones
- A. True True – reason correctly explains assertion
- B. True True – both statements are true but the reason does not explain the assertion
- C. True False
- D. False True
- E. False False
Correct

Incorrect
Question 18 of 20

18. Question
1 point(s)
Anaemia is defined as ‘a haemoglobin level 20g/l below the lower limit of normal or a haemoglobin level less than 100g/l.
- A. True
- B. False
Correct

Incorrect
Question 19 of 20

19. Question
1 point(s)
The acronym “CRAB” is sometimes used to refer to the most frequent features of myeloma at presentation: Compression (of the spinal cord), Renal insufficiency, Anaemia, Bone pain
- A. True
- B. False
Correct

Incorrect
Question 20 of 20

20. Question
1 point(s)
Can you match the correct term in the sentence below?

A trephine biopsy – X –
- Provides comprehensive information about the cellularity of the bone marrow
- Enables immunophenotyping to be performed
- Shows morphological features of myeloma cells better than an aspirate sample
- Is used for cytogenetic analysis
Correct

Incorrect

MNLP – Module 3 – Final assessment