Diagnostic tests and prognostic indicators

Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy. Mathis S et al. Cytometry B Clin Cytom. 2014 Oct 28. doi: 10.1002/cytob.21200. [Epub ahead of print]. Early relapse after single auto-SCT for multiple myeloma is a major predictor of survival in the era of…

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Related conditions

Unveiling Skeletal Fragility in Patients Diagnosed with MGUS: No Longer a Condition of Undetermined Significance? Drake MT. J Bone Miner Res. 2014 Oct 15. doi: 10.1002/jbmr.2387. [Epub ahead of print]. A systemic disease un…suspected by physical examination. Costa C et al. BMJ Case Rep. 2014 Oct 9;2014. pii: bcr2014205919. doi: 10.1136/bcr-2014-205919. How I treat smoldering…

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Emerging treatments

Panobinostat in combination with bortezomib and dexamethasone as induction therapy in patients with multiple myeloma candidates to autologous transplant. Mangiacavalli S et al. Leuk Lymphoma. 2014 Oct 27:1-8. [Epub ahead of print]. Bendamustine in combination with thalidomide and dexamethasone is a viable salvage option in myeloma relapsed and/or refractory to bortezomib and lenalidomide. Lau IJ…

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Biology and genetics

Immune impairments in multiple myeloma bone marrow mesenchymal stromal cells. AndrĂ© T et al. Cancer Immunol Immunother. 2014 Oct 24. [Epub ahead of print]. Inhibition of Akt-signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy. van der Waart AB et al. Blood. 2014 Oct 21. pii: blood-2014-05-578583. [Epub ahead of print]. Global…

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Supportive care

Pegfilgrastim in primary prophylaxis of febrile neutropenia during chemotherapy of relapsed and refractory multiple myeloma: a real-life experience. Cerchione C et al. Support Care Cancer. 2014 Oct 24. [Epub ahead of print]. Bisphosphonates do not delay engraftment after autologous SCT in patients with newly diagnosed myeloma. Oksman MJ et al. Bone Marrow Transplant. 2014 Oct…

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General

Haematological cancer: Optimizing the treatment of multiple myeloma. Morgan GJ et al. Nat Rev Clin Oncol. 2014 Oct 28. doi: 10.1038/nrclinonc.2014.185. [Epub ahead of print]. The Role of Bendamustine in the Management of Plasma Cell Myeloma. Gertz MA. Leuk Lymphoma. 2014 Oct 27:1-5. [Epub ahead of print]. Non-hodgkin lymphoma risk and insecticide, fungicide and fumigant…

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Complications of myeloma and its treatments

Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients. Blimark C et al. Haematologica. 2014 Oct 24. pii: haematol.2014.107714. [Epub ahead of print]. Drug-Induced Modulation of T Lymphocytes as a Potential Mechanism of Susceptibility to Infections in Patients with Multiple Myeloma During Bortezomib Therapy. Li J et al. Cell Biochem Biophys. 2014…

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Current treatments

Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma. Tuchman SA et al. J Clin Apher. 2014 Oct 8. doi: 10.1002/jca.21360. [Epub ahead of print]. Improved response rates with bortezomib in relapsed or refractory multiple myeloma: an observational study in chinese patients. Lin M et al. Adv Ther. 2014…

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