2017 ASCO preview

The abstracts for the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting, released earlier this month, indicate that the main areas of interest in myeloma this year focus on novel treatment combinations including daratumumab (Darzalex®), other anti-CD38 antibodies, checkpoint inhibitors, pomalidomide (Imnovid®), carfilzomib (Kyprolis®) and venetoclax. In total, 84 abstracts on myeloma and related…

Details

IMWG publishes consensus on second primary malignancies in myeloma

The International Myeloma Working Group (IMWG) has published a consensus statement providing practical recommendations for managing myeloma patients who develop second primary malignanices (SPMs). Published in the Annals of Oncology, the group reviewed the latest evidence of possible host-, disease- and treatment-related risk factors for the development of SPMs in myeloma patients. They recommend that…

Details

Diagnostic techniques and prognostic indicators

Identification of pathway-based prognostic gene signatures in patients with multiple myeloma. Zamani-Ahmadmahmudi M et al. Transl Res. 2017 May 9. pii: S1931-5244(17)30041-5. doi: 10.1016/j.trsl.2017.05.001. [Epub ahead of print]. Comparative proteomic profiling of sera from patients with refractory multiple myeloma reveals potential biomarkers predicting response to bortezomib-based therapy. Łuczak M, Kubicki T et al. Pol Arch Intern Med. 2017 May 25. doi: 10.20452/pamw.4032. [Epub ahead of…

Details

Related conditions

Incidence, characteristics and outcome of solitary plasmacytoma and plasma cell leukemia. Population based data from the Swedish Myeloma Register. Nahi H et al. Eur J Haematol. 2017 May 22. doi: 10.1111/ejh.12907. [Epub ahead of print]. Expression of the IL-6 receptor alpha-chain (CD126) in normal and abnormal plasma cells in monoclonal gammopathy of undetermined significance and smoldering myeloma. Salem DA et al. Leuk Lymphoma. 2017…

Details

Emerging treatments

Haematological cancer: Pembrolizumab is effective in multiple myeloma. Sidaway P. Nat Rev Clin Oncol. 2017 May 23. doi: 10.1038/nrclinonc.2017.76. [Epub ahead of print]. A Phase 1b study of isatuximab plus lenalidomide and dexamethasone for relapsed/refractorymultiple myeloma. Martin T et al. Blood. 2017 May 8. pii: blood-2016-09-740787. doi: 10.1182/blood-2016-09-740787. [Epub ahead of print]. Pembrolizumab, pomalidomide and low dose dexamethasone for relapsed/refractory multiple myeloma.…

Details

Biology and genetics

The level of deletion 17p and bi-allelic inactivation of TP53 has a significant impact on clinical outcome in multiple myeloma. Thanendrarajan S et al. Haematologica. 2017 May 26. pii: haematol.2017.168872. doi: 10.3324/haematol.2017.168872. [Epub ahead of print]. Somatic mutation spectrum in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape compared to multiple myeloma. Mikulasova A et al. Haematologica. 2017 May 26.…

Details

General

Experiences of establishing an academic early phase clinical trials unit. Brown SR et al. Clin Trials. 2017 May 1:1740774517710250. doi: 10.1177/1740774517710250. [Epub ahead of print]. Minimal Residual Disease Negativity Is a New End Point of Myeloma Therapy. Harousseau JL et al. J Clin Oncol. 2017 May 19:JCO2017731331. doi: 10.1200/JCO.2017.73.1331. [Epub ahead of print]. Race colors transplantation utilization for multiple myeloma. Majhail NS et al. Cancer. 2017 May…

Details

Complications of myeloma and its treatments

Cardiovascular events during carfilzomib therapy for relapsed myeloma: practical management aspects from two case studies. Jakubowiak AJ et al. Hematology. 2017 May 25:1-7. doi: 10.1080/10245332.2017.1328165. [Epub ahead of print]. Clinical conditions responsible for hyperviscosity and skin ulcers complications. Caimi G et al. Clin Hemorheol Microcirc. 2017 May 19. doi: 10.3233/CH-160218. [Epub ahead of print]. Increased risk of arterial thromboembolic events with combination…

Details

Current treatments

Bortezomib, Thalidomide, and Dexamethasone (VTD) Induction Results in Better Overall Survival than Adriamycin, Thalidomide, and Dexamethasone (ATD) Induction in Previously UntreatedMyeloma Patients Eligible for Transplants. Chen JF et al. Acta Haematol. 2017 May 5;137(4):207-208. doi: 10.1159/000471839. [Epub ahead of print]. Successful treatment of patients with newly diagnosed/untreated light chain multiple myeloma with a combination of bendamustine, prednisone and bortezomib (BPV). Tessenow…

Details