A recent study, conducted by the International Myeloma Working Group (IMWG), has demonstrated the benefits of whole body computed tomography (WBCT) compared to conventional skeletal survey (CSS) for identifying osteolytic lesions in myeloma. The study, published in Blood Cancer Journal, found that WBCT is more sensitive than CSS in detecting skeletal lesions, with 20-25% patients…
A study, funded by Myeloma UK, has demonstrated that neutral tumour evolution in myeloma is associated with poorer prognosis. Neutral evolution is the term used to describe evolution caused by random genetic mutations and are normally considered to be neither beneficial nor detrimental to survival. However, in this study, such tumours conferred a worse prognosis…
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Therapeutic monoclonal antibodies in combination with pomalidomide can overcome refractoriness to both agents in multiple myeloma: A case-based approach. Baertsch MA et al. Hematol Oncol. 2017 Aug 25. doi: 10.1002/hon.2473. [Epub ahead of print]. Evolutionary biology of high-risk multiple myeloma. Pawlyn C et al. Nat Rev Cancer. 2017 Aug 24;17(9):543-556. doi: 10.1038/nrc.2017.63. Comprehensive Evaluation of the Revised International Staging System in Multiple Myeloma Patients…
The activity and safety of novel proteasome inhibitors strategies (single, doublet and triplet) for relapsed/refractory multiple myeloma. Ma H et al. Acta Oncol. 2017 Aug 22:1-7. doi: 10.1080/0284186X.2017.1364868. [Epub ahead of print]. Real world data of the impact of first cycle daratumumab on multiple myeloma and AL amyloidosis services. Popat R et al. Br J Haematol. 2017 Aug 18. doi: 10.1111/bjh.14897. [Epub ahead of…
Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group. Hillengass J et al. Blood Cancer J. 2017 Aug 25;7(8):e599. doi: 10.1038/bcj.2017.78. High sensitivity blood-based M-protein detection in sCR patients with multiple myeloma. Mills JR et al. Blood Cancer J. 2017 Aug 25;7(8):e590. doi: 10.1038/bcj.2017.75. Evaluation of pretreatment red cell distribution…
Results of Prospective Randomized, Open Label, Non -Inferiority Study of Tbo-Filgrastim (Granix®) Versus Filgrastim (Neupogen®) in Combination with Plerixafor for Autologous Stem Cell Mobilization in Patients with Multiple Myeloma or Non -Hodgkin Lymphoma. Bhamidipati PK et al. Biol Blood Marrow Transplant. 2017 Aug 7. pii: S1083-8791(17)30619-5. doi: 10.1016/j.bbmt.2017.07.023. [Epub ahead of print]. Multiple myeloma with extramedullary disease: impact of autologous stem…
Uterine Extramedullary Plasmacytoma as a Primary Manifestation of Multiple Myeloma. Codorniz A et al. Rev Bras Ginecol Obstet. 2017 Aug 23. doi: 10.1055/s-0037-1605373. [Epub ahead of print]. Autoimmune HIT due to apheresis catheter heparin flushes for stem-cell harvesting before autotransplantation for myeloma. Mian H et al. Blood. 2017 Aug 22. pii: blood-2017-06-788679. doi: 10.1182/blood-2017-06-788679. [Epub ahead of print]. Infectious complications in multiple myeloma receiving autologous…
Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Tenreiro MM et al. Angiogenesis. 2017 Aug 24. doi: 10.1007/s10456-017-9571-8. [Epub ahead of print]. Intracellular light chain crystals in myeloma. Staubach ZG et al. Blood. 2017 Aug 24;130(8):1070. doi: 10.1182/blood-2017-04-779207. Logic programming reveals alteration of key transcription factors in multiple myeloma. Miannay B et al. Sci Rep. 2017 Aug 23;7(1):9257. doi: 10.1038/s41598-017-09378-9. Oncolytic…