NICE to consider lenalidomide maintenance treatment for myeloma patients post high dose therapy and stem cell transplantation

Lenalidomide (Revlimid®) maintenance for myeloma patients who have undergone high dose therapy and stem cell transplantation (HDT-SCT) will be considered for use on the NHS by The National Institute for Health and Care Excellence (NICE) later this year. This announcement comes after updated advice from the manufacturer Celgene and follows publication of data from the Myeloma XI clinical…

News

60th American Society of Haematology Annual Meeting (ASH) Research Highlights

OPTIMISING CURRENT TREATMENTS The number of drugs available as myeloma treatment has grown significantly over the last two decades with discovery and approval of immunomodulatory drugs (thalidomide, lenalidomide (Revlimid®) and pomalidomide (Imnovid®)), proteasome inhibitors (bortezomib (Velcade®), cafilzomib (Kyprolis®) and ixazomib (Ninlaro®)), histone deacetylase inhibitors (panobinostat) and monoclonal antibody drugs (daratumumab (Darzalex®) and elotuzumab (Empliciti®)). However,…

Meeting highlights, Meetings and events

Diagnostic techniques and prognostic indicators

Whole-Body MR Imaging: The Novel, “Intrinsically Hybrid,” Approach to Metastases, Myeloma, Lymphoma, in Bones and Beyond. Lecouvet FE et al. PET Clin. 2018 Oct. doi: 10.1016/j.cpet.2018.05.006. [Epub 2018 Aug 17] Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis. Leiba M et al. Oral Dis. 2018 Oct. doi: 10.1111/odi.12901.…

Diagnosing and Monitoring Myeloma, Journal, Library

Current treatments

Determining treatment intensity in elderly patients with multiple myeloma. Salvini M et al. Expert Rev Anticancer Ther. 2018 Sep. doi: 10.1080/14737140.2018.1496823. [Epub 2018 Jul 13] Treatment patterns and medication adherence among patients diagnosed with multiple myeloma and treated with panobinostat. Chari A et al. Future Oncol. 2018 Sep. doi: 10.2217/fon-2017-0727. [Epub 2018 May 30] Autologous stem cell transplantation in first…

Journal, Library

General

The Multiple Myeloma Drug Pipeline-2018: A Review of Small Molecules and Their Therapeutic Targets. Abramson HN. Clin Lymphoma Myeloma Leuk. 2018 Sep. doi: 10.1016/j.clml.2018.06.015. [Epub 2018 Jun 18] A new conceptual framework for the therapy by optimized multidimensional pulses of therapeutic activity. The case of multiple myeloma model. Horvath D and Brutovsky B. J Theor Biol. 2018 Oct 7. doi: 10.1016/j.jtbi.2018.06.015. [Epub 2018 Jun…

Journal, Library

Biology and genetics

Bortezomib Targets Sp Transcription Factors in Cancer Cells. Karki Ket al. Mol Pharmacol. 2018 Oct. doi: 10.1124/mol.118.112797. [Epub 2018 Aug 16] IRF4 in multiple myeloma-Biology, disease and therapeutic target. Agnarelli A et al. Leuk Res. 2018 Sep. doi: 10.1016/j.leukres.2018.07.025. [Epub 2018 Aug 3] PGC1β regulates multiple myeloma tumor growth through LDHA-mediated glycolytic metabolism. Zhang H et al. Mol Oncol. 2018 Sep.…

Journal, Library, Management of Myeloma