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miR-26b-5p suppresses proliferation and promotes apoptosis in multiple myeloma cells by targeting JAG1. Jian CM et al. Pathol Res Pract. 2018 Sep. doi: 10.1016/j.prp.2018.07.025. [Epub 2018 Jul 27] Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis. Zeng C et al. Oncol Rep. 2018 Sep. doi: 10.3892/or.2018.6544.…
Altered microRNA expression profile in the peripheral lymphoid compartment of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw. Musolino C et al. Ann Hematol. 2018 Mar 15. doi: 10.1007/s00277-018-3296-7. [Epub ahead of print]. A novel nano-immunoassay method for quantification of proteins from CD138 purified myeloma cells: biological and clinical utility. Misiewicz-Krzeminska I et al. Haematologica. 2018 Mar 15. pii: haematol.2017.181628. doi: 10.3324/haematol.2017.181628. [Epub ahead…
Myeloid transformation of plasma cell myeloma: molecular evidence of clonal evolution revealed by next generation sequencing. Gralewski JH et al. Diagn Pathol. 2018 Feb 20;13(1):15. doi: 10.1186/s13000-018-0692-1. The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor. Du Y et al. J Biol Chem. 2018 Feb 21. pii: jbc.RA117.000972. doi: 10.1074/jbc.RA117.000972. [Epub ahead of print]. Loss of heterozygosity…
Isolation of circulating plasma cells from blood of patients diagnosed with clonal plasma cell disorders using cell selection microfluidics. Kamande JW et al. Integr Biol (Camb). 2018 Jan 26. doi: 10.1039/c7ib00183e. [Epub ahead of print]. Truncated protein tyrosine phosphatase receptor type O suppresses AKT signaling through IQ motif containing GTPase activating protein 1 and confers sensitivity to bortezomib…
DNA damage response-initiated cytokine secretion in bone marrow stromal cells promotes chemoresistance of myeloma cells. Tang H et al. Leuk Lymphoma. 2017 Dec 18:1-7. doi: 10.1080/10428194.2017.1413188. [Epub ahead of print]. Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo. Zhou L et al. Br J Cancer. 2017 Dec 14. doi: 10.1038/bjc.2017.432. [Epub ahead of print]. Jagged1-induced Notch activation contributes to…
MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells. Botta C et al. Leukemia. 2017 Nov 21. doi: 10.1038/leu.2017.336. [Epub ahead of print]. Protein arginine methyltransferase 5 (PRMT5) has prognostic relevance and is a druggable target in multiple myeloma. Gullà A et al.Leukemia. 2017 Nov 21. doi: 10.1038/leu.2017.334. [Epub ahead of print]. Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences…
High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma. Sun Y et al. Cancer Lett. 2017 Oct 12. pii: S0304-3835(17)30629-8. doi: 10.1016/j.canlet.2017.10.005. [Epub ahead of print]. Characterization and use of the novel human multiple myelomacell line MC-b11/14 to study biological consequences of CRISPR-mediated loss of immunoglobulin a heavy chain. Walters DK et al. Exp Hematol. 2017 Oct 10. pii: S0301-472X(17)30814-7.…
Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis. Wang S et al. Cell Death Dis. 2017 Sep 21;8(9):e3058. doi: 10.1038/cddis.2017.450. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Mroczek S et al. Nat Commun. 2017 Sep 20;8(1):619. doi: 10.1038/s41467-017-00578-5. Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase. Dorasamy MS et al. J…
Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Tenreiro MM et al. Angiogenesis. 2017 Aug 24. doi: 10.1007/s10456-017-9571-8. [Epub ahead of print]. Intracellular light chain crystals in myeloma. Staubach ZG et al. Blood. 2017 Aug 24;130(8):1070. doi: 10.1182/blood-2017-04-779207. Logic programming reveals alteration of key transcription factors in multiple myeloma. Miannay B et al. Sci Rep. 2017 Aug 23;7(1):9257. doi: 10.1038/s41598-017-09378-9. Oncolytic…