General

United Kingdom Myeloma Forum position statement on the use of consolidation and maintenance treatment in myeloma. Rabin N et al. Int J Lab Hematol. 2014 Mar 27. doi: 10.1111/ijlh.12205. [Epub ahead of print]. Autologous haematopoietic stem cell mobilisation in multiple myeloma and lymphoma patients: a position statement from the European Group for Blood and Marrow…

Emerging treatments

Monoclonal antibodies currently in Phase II and III trials for multiple myeloma.Donato F et al. Expert Opin Biol Ther. 2014 Apr 21. [Epub ahead of print].Outcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide.Yee AJ et al. Br J Haematol. 2014 Apr 25. doi:…

Biology and genetics

Jumping translocations and high-risk myeloma. Morgan GJ et al. Blood. 2014 Apr 17;123(16):2442-3. doi: 10.1182/blood-2014-02-555755. NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis. Ni H et al. PLoS One. 2014 Apr 22;9(4):e95846. doi: 10.1371/journal.pone.0095846. eCollection 2014. Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple…

Supportive care

Advances in supportive care for multiple myeloma.Raje NS et al. J Natl Compr Canc Netw. 2014 Apr 1;12(4):502-11.Surgical management of primary tumors of the cervical spine: surgical considerations and avoidance of complications.Kaloostian PE et al. Neurol Res. 2014 Apr 10:1743132814Y0000000367. [Epub ahead of print].Post-operative Cement Augmentation after 360-degree Fusion for Highly Unstable Vertebral Fractures in…

Current treatments

Bortezomib cumulative dose, efficacy, and tolerability with three different bortezomib-melphalan-prednisone regimens in previously untreated myeloma patients ineligible for high-dose therapy.Mateos MV et al. Haematologica. 2014 Apr 24. [Epub ahead of print].Early response-based intensification of primary therapy in newly diagnosed multiple myeloma patients who are eligible for autologous stem cell transplantation: phase II study.Ahn SY et…

Diagnostic tests and prognostic indicators

CD14+ CD16+ monocytes rather than CD14+ CD51/61+ monocytes are a potential cytological marker of circulating osteoclast precursors in multiple myeloma. A preliminary study. Petitprez V et al. Int J Lab Hematol. 2014 Mar 24. doi: 10.1111/ijlh.12216. [Epub ahead of print]. Prognostic value of deep sequencing method for minimal residual disease detection in multiple myeloma. Martinez-Lopez…

Biology and genetics

Autophagy in Plasma Cell Pathophysiology. Oliva L et al. Front Immunol. 2014 Mar 12;5:103. eCollection 2014. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Olsen OE et al. Blood Cancer J. 2014 Mar 21;4:e196. doi: 10.1038/bcj.2014.16. Phenotypic, Genomic and Functional Characterization Reveals No Differences between CD138++…

General

Survival of Multiple Myeloma Patients Aged 65-70 Years in the Era of Novel Agents and Autologous Stem Cell Transplantation. A Multicenter Retrospective Collaborative Study of the Japanese Society of Myeloma and the European Myeloma Network. Ozaki S et al. Acta Haematol. 2014 Mar 22;132(2):211-219. [Epub ahead of print]. Pathways for blood and bowel cancer patients…