Diagnostic techniques and prognostic indicators

Multiple myeloma can be accurately diagnosed in acute kidney injury patients using a rapid serum free light chain test. Heaney JLJ et al. BMC Nephrol. 2017 Jul 20;18(1):247. doi: 10.1186/s12882-017-0661-z. Prognostic Validation of SKY92 and Its Combination With ISS in an Independent Cohort of Patients With Multiple Myeloma. van Beers EH et al. Clin Lymphoma Myeloma Leuk. 2017 Jul 4. pii: S2152-2650(17)30278-1. doi: 10.1016/j.clml.2017.06.020. [Epub…

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Current treatments

Efficacy and Safety of Bortezomib Maintenance in Patients with Newly Diagnosed Multiple Myeloma: A Meta-Analysis. Sun CY et al. Biosci Rep. 2017 Jul 13. pii: BSR20170304. doi: 10.1042/BSR20170304. [Epub ahead of print]. Targeting complete response with upfront bortezomib consolidation versus observation after the achievement of complete response following autologous transplantation for multiple myeloma(TUBA study). Nakasone H et al. Hematol Oncol. 2017 Jul 6.…

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Complications of myeloma and its treatments

Immunoglobulin A nephropathy in a patient with IgG kappa light-chain myeloma. Chandra A et al. Saudi J Kidney Dis Transpl. 2017 Jul-Aug;28(4):937-941. Priapism with penile gangrene: An unusual presentation of multiple myeloma. Panwar VK et al. Indian J Urol. 2017 Jul-Sep;33(3):251-252. doi: 10.4103/iju.IJU_41_17. Increased corneal densitometry as a subclinical corneal change associated with multiple myeloma. Busch C et al. Eye (Lond). 2017 Jul 14. doi: 10.1038/eye.2017.132. [Epub…

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Biology and genetics

The first-in-class alkylating HDAC inhibitor EDO-S101 is highly synergistic with proteasome inhibition against multiple myeloma through activation of multiple pathways. Besse L et al. Blood Cancer J. 2017 Jul 28;7(7):e589. doi: 10.1038/bcj.2017.69. A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo. Hipp S et al. Leukemia. 2017 Jul 28. doi: 10.1038/leu.2017.219. [Epub ahead of print].…

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Diagnostic techniques and prognostic indicators

Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests. Heaney JLJ et al. Br J Haematol. 2017 Jun 1. doi: 10.1111/bjh.14753. [Epub ahead of print]. Circulating adiponectin levels differ between patients with multiple myeloma and its precursor disease. Hofmann JN et al. Obesity (Silver Spring). 2017 Jun 11. doi: 10.1002/oby.21894. [Epub ahead of print]. Diffusion-weighted whole-body MRI for…

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Related conditions

Daratumumab yields rapid and deep hematologic responses in patients with heavily pretreated AL amyloidosis. Kaufman GP et al. Blood. 2017 Jun 14. pii: blood-2017-01-763599. doi: 10.1182/blood-2017-01-763599. [Epub ahead of print]. The role of frontline autologous stem cell transplantation for primary plasma cell leukemia: a retrospective multicenter study (KMM160). Jung SH et al. Oncotarget. 2017 Jun 16. doi: 10.18632/oncotarget.18535. [Epub ahead of…

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Emerging treatments

MEK inhibitors in oncology: a patent review (2015-Present). Mahapatra DK et al. Expert Opin Ther Pat. 2017 Jun 19:1-20. doi: 10.1080/13543776.2017.1339688. [Epub ahead of print]. Elotuzumab as a novel anti-myeloma immunotherapy. Radhakrishnan SV et al. Hum Vaccin Immunother. 2017 Jun 12:1-7. doi: 10.1080/21645515.2017.1327487. [Epub ahead of print]. Sending CAR T Cells After Multiple Myeloma. [No authors listed]. Cancer Discov. 2017 Jun 6. doi: 10.1158/2159-8290.CD-NB2017-088. [Epub…

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Biology and genetics

A novel dual inhibitor of microtubule and Bruton’s Tyrosine Kinase inhibits survival of multiple myeloma and osteoclastogenesis. Pandey MK et al. Exp Hematol. 2017 Jun 21. pii: S0301-472X(17)30233-3. doi: 10.1016/j.exphem.2017.06.003. [Epub ahead of print]. Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma. Laganà A et al. Leukemia. 2017 Jun 23. doi: 10.1038/leu.2017.197. [Epub ahead of print]. Changes…

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General

Living with the burden of relapse in multiple myeloma from the patient and physician perspective. Hulin C et al. Leuk Res. 2017 May 31;59:75-84. doi: 10.1016/j.leukres.2017.05.019. [Epub ahead of print]. The impact of comorbidity on mortality in multiple myeloma: a Danish nationwide population-based study. Gregersen H et al. Cancer Med. 2017 Jun 22. doi: 10.1002/cam4.1128. [Epub ahead of print]. Recent advances in understanding multiple myeloma.…

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