Myeloma is a relapsing-remitting blood cancer arising from the clonal expansion of abnormal plasma cells in the bone marrow. It is a difficult cancer to diagnose due to the vagueness of symptoms and rarity of the disease. This means myeloma patients experience some of the longest delays in diagnosis of all cancer patients. Myeloma UK…
DetailsThis new treatment combination is being made available via the CDF on the NHS for the first time following a recommendation by the National Institute of Health and Care Excellence (NICE). This decision follows an earlier draft negative decision by NICE in July last year. Daratumumab, which is produced by the pharmaceutical company Janssen, belongs to a…
DetailsThe IMWG present updated recommendations for the treatment of vertebral compression fractures in patients with myeloma by cement augmentation
As whole-body MRI is listed in NICE guidance as the recommended first line imaging in patients with suspected myeloma, this paper outlines a clinical protocol: the Myeloma Response Assessment and Diagnosis System (MY-RADS), for its use and interpretation.
The Myeloma Diagnosis Pathway is an easy to follow, quick reference tool to help GPs and other healthcare professionals recognise the signs and symptoms of myeloma. It provides information on which tests and investigations should be conducted before referral to a haematologist. It has been designed by Myeloma UK and reviewed by a working group…
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Finding answers to discover a cure for myeloma is one of our main objectives at Myeloma UK. We are committed to achieving this with the help of supporters such as Alison Goldberg and Sara Phillips, who are trustees of The Joyce and Norman Freed Charitable Trust, which they established in 2016 to help fund projects…
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OPTIMISING CURRENT TREATMENTS The number of drugs available as myeloma treatment has grown significantly over the last two decades with discovery and approval of immunomodulatory drugs (thalidomide, lenalidomide (Revlimid®) and pomalidomide (Imnovid®)), proteasome inhibitors (bortezomib (Velcade®), cafilzomib (Kyprolis®) and ixazomib (Ninlaro®)), histone deacetylase inhibitors (panobinostat) and monoclonal antibody drugs (daratumumab (Darzalex®) and elotuzumab (Empliciti®)). However,…
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Common Terminology Criteria for Adverse Events (CTCAE) is widely accepted as the standard classification and severity grading scale for adverse events in cancer therapy, clinical trials and other oncology settings. Version 5.0 is the most updated document (November 27, 2017)
The European Myeloma Network have published recommendations on diagnostic, prognostic and monitoring tests for patients with myeloma.