Results from the national Myeloma XI trial have shown a higher incidence of second primary malignancies (SPM) in patients receiving Revlimid (lenalidomide) maintenance treatment compared to those who did not, in line with other previous reported trials. Published in the Blood Cancer Journal analysis of the data showed that, although the overall incidence of SPM was…
Celgene, the Dana-Farber Cancer Institute and the University of Arkansas for Medical Sciences (UAMS) have announced that they have partnered to create the Myeloma Genome Project to compile high quality genetic and clinical data to improve diagnosis, prognosis and treatment for myeloma patients. The aim is to develop a strategy for classifying myeloma into subgroups…
Multiple myeloma treatment at relapse after autologous stem cell transplantation: A practical analysis. Malard F et al. Cancer Treat Rev. 2016 Nov 15;52:41-47. doi: 10.1016/j.ctrv.2016.11.005. [Epub ahead of print]. Second primary malignancies in multiple myeloma: an overview and IMWG consensus. Musto P et al. Ann Oncol. 2016 Nov 17. pii: mdw606. [Epub ahead of print]. Aging, ‘Treating the Older Patient’. Rosko A et al. Biol…
Palonosetron, aprepitant, and dexamethasone for prevention of nausea and vomiting after high-dose melphalan in autologous transplantation for multiple myeloma: A phase II study. Isoda A et al. Int J Hematol. 2016 Nov 21. [Epub ahead of print]. Biosimilar epoetin for the management of chemotherapy-induced anemia in elderly patients. Kurtz JE et al. Onco Targets Ther. 2016 Oct 28;9:6689-6693. eCollection 2016. Percutaneous sacroplasty…
Secondary primary malignancies during the lenalidomide-dexamethasone regimen in relapsed/refractorymultiple myeloma patients. Kotchetkov R et al. Cancer Med. 2016 Nov 18. doi: 10.1002/cam4.799. [Epub ahead of print]. Safety of proteasome inhibitors for treatment of multiple myeloma. Schlafer D et al. Expert Opin Drug Saf. 2016 Nov 14. [Epub ahead of print]. Ixazomib Cardiotoxicity: A Possible Class Effect of Proteasome Inhibitors. Jouni H et al. Am J…
Patients’ outcome after rescue plerixafor administration for autologous stem cell mobilization: a single-center retrospective analysis. Spoerl S et al. Transfusion. 2016 Nov 18. doi: 10.1111/trf.13883. [Epub ahead of print]. Maintenance Versus Induction Therapy Choice on Outcomes after Autologous Transplantation for Multiple Myeloma. Cornell RF et al. Biol Blood Marrow Transplant. 2016 Nov 15. pii: S1083-8791(16)30489-X. doi: 10.1016/j.bbmt.2016.11.011. [Epub ahead of print]. Absence…
A study, funded by Myeloma UK, has discovered a mechanism that may explain how a genetic variant increases the risk of developing myeloma. Published in the latest issue of Nature Communications, researchers at The Institute of Cancer Research, London investigated the functional effects of the most highly associated variant they had identified from a previously conducted…
The Myeloma UK Clinical Trial Network (CTN) has achieved another significant milestone with data from the MUK six trial published in the latest issue of Lancet Haematology. MUK six, a Phase I/II multicentre open label trial aimed to determine the safety and both the optimum and maximum dose of panobinostat when used in combination with once-weekly Velcade,…
High-risk multiple myeloma: a multifaceted entity, multiple therapeutic challenges. Muchtar E et al. Leuk Lymphoma. 2016 Oct 13:1-14. [Epub ahead of print]. Is the revised International staging system for myeloma valid in a real world population? Walker I et al. Br J Haematol. 2016 Oct 13. doi: 10.1111/bjh.14341. [Epub ahead of print]. Progress in Myeloma – A Monoclonal Breakthrough. Rajkumar SV et al. N Engl J Med. 2016 Oct 6;375(14):1390-1392. Next-generation multiple…
A population-based study of the impact of dialysis on mortality in multiple myeloma. Evison F et al. Br J Haematol. 2016 Oct 21. doi: 10.1111/bjh.14394. [Epub ahead of print]. Efficacy and Safety of Danshen Compound Tablets in Preventing Thalidomide-Associated Thromboembolism in Patients with Multiple Myeloma: A Multicenter Retrospective Study. Yin QS et al. Med Sci Monit. 2016 Oct 20;22:3835-3842. Effect of Systemic Therapies…