Related conditions

Translocation t(11;14) Is Associated With Adverse Outcome in Patients With Newly Diagnosed AL Amyloidosis When Treated With Bortezomib-Based Regimens. Bochtler T et al. J Clin Oncol. 2015 Mar 16. pii: JCO.2014.57.4947. [Epub ahead of print]. Extracorporeal Membrane Oxygenation as Bridge-to-Decision in Acute Heart Failure due to Systemic Light-Chain Amyloidosis. Mancio Silva J et al. Am J Case Rep. 2015 Mar 24;15:174-81.…

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Emerging treatments

Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma. Seggewiss-Bernhardt R et al. Cancer. 2015 Mar 24. doi: 10.1002/cncr.29339. [Epub ahead of print]. O7.3BET-bromodomain (BRD) inhibitor OTX015: Final results of the dose-finding part of a phase I study in hematologic malignancies. Herait…

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Biology and Genetics

Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Kikuchi S et al. Leukemia. 2015 Mar 24. doi: 10.1038/leu.2015.83. [Epub ahead of print]. Structure-activity relationships of benzhydrol derivatives based on 1′-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-κB pathway. Misawa T et al. Bioorg Med Chem. 2015 Mar 7. pii: S0968-0896(15)00143-1. doi:…

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General

Panobinostat Approved for Multiple Myeloma. [No authors listed. Cancer Discov. 2015 Mar 23. [Epub ahead of print]. American Society of Hematology Annual Meeting 2014: highlights in multiple myeloma. Glavey SV et al. Expert Rev Hematol. 2015 Mar 24:1-3. [Epub ahead of print]. Recent advances in multiple myeloma. Kohgo Y et al. Int J Clin Oncol. 2015 Mar 20. [Epub ahead of print]. Patterns of total cost…

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Current treatments

Phase I/II study of melphalan, prednisone and lenalidomide combination for patients with newly diagnosed multiple myeloma who are not candidates for stem cell transplantation. Roy V et al. Blood Cancer J. 2015 Mar 20;5:e294. doi: 10.1038/bcj.2015.23. Phase III trial of bortezomib, cyclophosphamide, dexamethasone (VCD) versus bortezomib, doxorubicin, dexamethasone (PAd) in newly-diagnosed myeloma. Mai EK et al. Leukemia. 2015 Mar 19. doi: 10.1038/leu.2015.80. [Epub…

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Complications of myeloma and its treatments

Cytomegalovirus reactivation in patients with multiple myeloma. Hasegawa T et al. Eur J Haematol. 2015 Mar 21. doi: 10.1111/ejh.12551. [Epub ahead of print] Improvement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma. Gonsalves WI et al. Blood Cancer J. 2015 Mar 20;5:e296. doi: 10.1038/bcj.2015.20. Multiple myeloma presenting with a maxillary lesion as the first sign. Ramaiah KK et…

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Diagnostic tests and prognostic indicators

Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-Squares Estimation (IDEAL) Magnetic Resonance Imaging as a Biomarker for Symptomatic Multiple Myeloma. Takasu M et al. PLoS One. 2015 Feb 23;10(2):e0116842. doi: 10.1371/journal.pone.0116842. Serum free light chain reduction correlates with response and progression-free survival following carfilzomib therapy in relapsed/refractory multiple myeloma. Vij R et al. Leuk Lymphoma. 2015 Feb 20:1-12. [Epub ahead…

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Emerging treatments

Phase Ib/II trial of CYKLONE (cyclophosphamide, carfilzomib, thalidomide and dexamethasone) for newly diagnosed myeloma. Mikhael JR et al. Br J Haematol. 2015 Feb 13. doi: 10.1111/bjh.13296. [Epub ahead of print]. Everolimus (RAD001) Activity in Relapsed and/or Refractory Multiple Myeloma: A Phase I Study. Guenther A et al. Haematologica. 2015 Feb 14. pii: haematol.2014.116269. [Epub ahead of print]. Phase I/II Study of the Combination…

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Biology and genetics

Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells. Anastasiadou E et al. Int J Cancer. 2015 Feb 20. doi: 10.1002/ijc.29489. [Epub ahead of print]. BCL2L11/Bim as a dual-agent regulating autophagy and apoptosis in drug resistance. Dai Y et al. Autophagy. 2015 Feb 20:0. [Epub ahead of print]. Hyaluronan synthase 1: a mysterious enzyme with unexpected functions. Siiskonen H et…

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