Diagnostic tests and prognostic indicators

IgD multiple myeloma: Clinical, biological features and prognostic value of the serum free light chain assay. Djidjik R et al. Pathol Biol (Paris). 2015 Aug 17. pii: S0369-8114(15)00057-7. doi: 10.1016/j.patbio.2015.06.002. [Epub ahead of print]. Patient dose evaluation for the whole-body low-dose multidetector CT (WBLDMDCT) skeleton study in multiple myeloma (MM). Cretti F et al. Radiol Med. 2015 Aug 19. [Epub ahead of print]. Clinical…

Related conditions

Lenalidomide is safe and active in waldenström macroglobulinemia. Fouquet G et al. Am J Hematol. 2015 Aug 18. doi: 10.1002/ajh.24175. [Epub ahead of print]. Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine. Simeon V et al. Int J Mol Sci. 2015 Jul 30;16(8):17514-34. doi: 10.3390/ijms160817514. Treatment of Immunoglobulin Light Chain Amyloidosis: Mayo Stratification of Myeloma and…

Emerging treatments

Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma. Lokhorst HM et al. N Engl J Med. 2015 Aug 26. [Epub ahead of print]. Phase 2 trial of ixazomib in patients with relapsed multiple myeloma not refractory to bortezomib. Kumar SK et al. Blood Cancer J. 2015 Aug 14;4:e338. doi: 10.1038/bcj.2015.60. Panobinostat: the small molecule metalloenzyme inhibitor with marvelous anticancer activity. Ganai SA. Curr Top Med…

Biology and genetics

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias. Lionetti M et al. Oncotarget. 2015 Jul 20. [Epub ahead of print]. The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Follin-Arbelet V et al. Sci Rep. 2015 Aug 26;5:13001. doi: 10.1038/srep13001. Notch signaling deregulation in multiple myeloma: A rational molecular target. Colombo M et…

General

Re-invigorating rather than re-inventing the wheel: augmenting the impact of salvage autologous stem cell transplantation for multiple myeloma in the era of novel agents. Cook G. Bone Marrow Transplant. 2015 Aug 3. doi: 10.1038/bmt.2015.175. [Epub ahead of print]. IgG Lambda Myeloma Presenting as Plasmacytic Ascites: Case Report and Review of Literature. Mitra S et al. Indian J Hematol Blood Transfus. 2015 Dec;31(4):472-9. doi: 10.1007/s12288-014-0454-5.…

Complications of myeloma and its treatments

Rapid evolving into acute myeloid leukemia in a patient with multiple myeloma and concurrent myelodysplasia after VTD therapy. Gu ZH et al. Int J Clin Exp Med. 2015 Jun 15;8(6):10105-10108. Factors influencing extramedullary relapse after allogeneic transplantation for multiple myeloma. Vincent L et al. Blood Cancer J. 2015 Aug 21;5:e341. doi: 10.1038/bcj.2015.48. Hematopoietic cell transplantation in patients with medication-related osteonecrosis of the jaws. Mawardi…

Current treatments

Continuous Therapy Versus Fixed Duration of Therapy in Patients With Newly Diagnosed Multiple Myeloma. Palumbo A et al. J Clin Oncol. 2015 Aug 17. pii: JCO.2014.60.2466. [Epub ahead of print]. Impact of novel agents followed by autologous hematopoietic stem cell transplantation for multiple myelomapatients aged 65 years or older: a retrospective single Institutional analysis. Minoia C et al. Bone Marrow Transplant. 2015 Aug…

NICE issues new draft guidelines for end of life care

The National Institute for Health and Care Excellence (NICE) has issued draft guidelines for consultation to improve the care of adults during the last few days of life. The guidelines are meant to replace the Liverpool Care Pathway which were phased out in 2014. Key recommendations highlight the importance of communication and shared decision-making involving…

Publication of revised International Staging System for myeloma

The International Myeloma Working Group (IMWG) has revised the International Staging System (ISS) to enable better stratification of newly diagnosed myeloma patients. It now includes the detection of chromosomal abnormalities (CA) by interphase fluorescent in situ hybridisation (iFISH) and the measurement of serum lactate dehydrogenase (LDH) which, when combined with the previous ISS, provides powerful…