Current treatments

Bortezomib-thalidomide-based regimens improved clinical outcomes without increasing toxicity as induction treatment for untreated multiple myeloma: A meta-analysis of phase III randomized controlled trials. Huang H et al. Leuk Res. 2014 Jun 30. pii: S0145-2126(14)00188-X. doi: 10.1016/j.leukres.2014.06.009. [Epub ahead of print]. Long-term survival with cyclophosphamide, bortezomib and dexamethasone induction therapy in patients with newly diagnosed multiple…

Related conditions

Gastrointestinal Amyloidosis and Multiple Myeloma. Alahdab F et al. J Gen Intern Med. 2014 Jun 4. [Epub ahead of print]. Auto-SCT improves survival in systemic light chain amyloidosis: a retrospective analysis with 14-year follow-up. Parmar S et al. Bone Marrow Transplant. 2014 Jun 2. doi: 10.1038/bmt.2014.115. [Epub ahead of print]. Epidemiology of Monoclonal Gammopathy of…

General

Allogeneic Transplant in Multiple Myeloma: A Potential Renaissance in the Era of Novel Therapies? Richardson P. Biol Blood Marrow Transplant. 2014 Jun 20. pii: S1083-8791(14)00363-2. doi: 10.1016/j.bbmt.2014.06.013. [Epub ahead of print]. Bendamustine for the treatment of multiple myeloma in first-line and relapsed-refractory settings: a review of clinical trial data. Palumbo A et al. Leuk Lymphoma.…

Diagnostic tests and prognostic indicators

Predicting multiple myeloma disease activity by analyzing natural calcium isotopic composition. Gordon GW et al. Leukemia. 2014 Jun 12. doi: 10.1038/leu.2014.193. [Epub ahead of print]. Identification of cereblon binding proteins and relationship with response and survival following pomalidomide and dexamethasone in multiple myeloma. Zhu YX et al. Blood. 2014 Jun 9. pii: blood-2014-02-557819. [Epub ahead…

Emerging treatments

Phase 1 study of twice-weekly dosing of investigational oral proteasome inhibitor ixazomib in patients with relapsed and/or refractory multiple myeloma. Richardson PG et al. Blood. 2014 Jun 11. pii: blood-2014-01-548826. [Epub ahead of print]. A phase II trial of BAY 43-9006 (sorafenib) (NSC-724772) in patients with relapsing and resistant multiple myeloma: SWOG S0434. Srkalovic G…

Biology and genetics

A Novel Functional Role for MMSET in RNA Processing Based on the Link Between the REIIBP Isoform and Its Interaction with the SMN Complex. Mirabella F et al. PLoS One. 2014 Jun 12;9(6):e99493. doi: 10.1371/journal.pone.0099493. eCollection 2014. MicroRNA expression patterns in medullary and extramedullary plasmacytoma. Lin JJ et al. Blood Cancer J. 2014 Jun 27;4:e223.…

Supportive care

Patterns of Community-Based Opioid Prescriptions in People Dying of Cancer. Gagnon B et al. J Pain Symptom Manage. 2014 Jun 16. pii: S0885-3924(14)00309-1. doi: 10.1016/j.jpainsymman.2014.05.015. [Epub ahead of print]. Treatment of Metastatic Posterior Vertebral Body Osseous Tumors by Using a Targeted Bipolar Radiofrequency Ablation Device: Technical Note. Hillen TJ et al. Radiology. 2014 Jun 13:131664.…

Complications of myeloma and its treatments

Bisphosphonate-induced Osteonecrosis of the Maxilla Presenting as a Cicatricial Ectropion. Malik R et al. Orbit. 2014 Jun 12:1-3. [Epub ahead of print]. Trichoderma species fungemia after high-dose chemotherapy and autologous stem cell transplantation: a case report. Festuccia M et al. Transpl Infect Dis. 2014 Jun 11. doi: 10.1111/tid.12245. [Epub ahead of print]. Immune Defects in…

Current treatments

Bendamustine and prednisone in combination with bortezomib (BPV) in the treatment of patients with newly diagnosed/untreated multiple myeloma. Pönisch W et al. J Cancer Res Clin Oncol. 2014 Jun 19. [Epub ahead of print]. The choice of regimens based on bortezomib for patients with newly diagnosed multiple myeloma. He J et al. PLoS One. 2014…

Biology and genetics

Microenvironment and multiple myeloma spread. Ribatti D et al. Thromb Res. 2014 May;133 Suppl 2:S102-6. doi: 10.1016/S0049-3848(14)50017-5. The role of bone morphogenetic proteins in myeloma cell survival. Holien T et al. Cytokine Growth Factor Rev. 2014 May 9. pii: S1359-6101(14)00042-2. doi: 10.1016/j.cytogfr.2014.04.009. [Epub ahead of print]. Anacardic acid induces cell apoptosis associated with induction of…