The level of deletion 17p and bi-allelic inactivation of TP53 has a significant impact on clinical outcome in multiple myeloma. Thanendrarajan S et al. Haematologica. 2017 May 26. pii: haematol.2017.168872. doi: 10.3324/haematol.2017.168872. [Epub ahead of print]. Somatic mutation spectrum in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape compared to multiple myeloma. Mikulasova A et al. Haematologica. 2017 May 26.…
DetailsExperiences of establishing an academic early phase clinical trials unit. Brown SR et al. Clin Trials. 2017 May 1:1740774517710250. doi: 10.1177/1740774517710250. [Epub ahead of print]. Minimal Residual Disease Negativity Is a New End Point of Myeloma Therapy. Harousseau JL et al. J Clin Oncol. 2017 May 19:JCO2017731331. doi: 10.1200/JCO.2017.73.1331. [Epub ahead of print]. Race colors transplantation utilization for multiple myeloma. Majhail NS et al. Cancer. 2017 May…
DetailsVariability of high-dose melphalan exposure on oral mucositis in patients undergoing prophylactic low-level laser therapy.
Rodrigues GH et al. Lasers Med Sci. 2017 May 16. doi: 10.1007/s10103-017-2211-0. [Epub ahead of print].
G-CSF improves safety when you start the day after autologous transplant in multiple myeloma.
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Cardiovascular events during carfilzomib therapy for relapsed myeloma: practical management aspects from two case studies. Jakubowiak AJ et al. Hematology. 2017 May 25:1-7. doi: 10.1080/10245332.2017.1328165. [Epub ahead of print]. Clinical conditions responsible for hyperviscosity and skin ulcers complications. Caimi G et al. Clin Hemorheol Microcirc. 2017 May 19. doi: 10.3233/CH-160218. [Epub ahead of print]. Increased risk of arterial thromboembolic events with combination…
DetailsBortezomib, Thalidomide, and Dexamethasone (VTD) Induction Results in Better Overall Survival than Adriamycin, Thalidomide, and Dexamethasone (ATD) Induction in Previously UntreatedMyeloma Patients Eligible for Transplants. Chen JF et al. Acta Haematol. 2017 May 5;137(4):207-208. doi: 10.1159/000471839. [Epub ahead of print]. Successful treatment of patients with newly diagnosed/untreated light chain multiple myeloma with a combination of bendamustine, prednisone and bortezomib (BPV). Tessenow…
DetailsSerum free light chain quantitative assays: Dilemma of a biomarker. Cigliana G et al. J Clin Lab Anal. 2017 Apr 26. doi: 10.1002/jcla.22243. [Epub ahead of print]. The utility of MASS-FIX to detect and monitor monoclonal proteins in the clinic. Milani P et al. Am J Hematol. 2017 Apr 25. doi: 10.1002/ajh.24772. [Epub ahead of print]. Heavy/light chain ratio for…
DetailsIgG4-related disease with bone marrow involvement mimicking multiple myeloma. Tang SH et al. Br J Haematol. 2017 Apr 25. doi: 10.1111/bjh.14651. [Epub ahead of print]. Impact of Autologous Stem Cell Transplantation on the Incidence and Outcome of Oligoclonal Bands in Patients with Light-Chain Amyloidosis. Rodríguez-Lobato LG et al. Biol Blood Marrow Transplant. 2017 Apr 18. pii: S1083-8791(17)30400-7. doi: 10.1016/j.bbmt.2017.04.012. [Epub ahead of print]. Crystalglobulinemia manifesting as chronic arthralgia…
DetailsPhase I trial of systemic administration of edmonston strain of measles virus, genetically engineered to express the sodium iodide symporter in patients with recurrent or refractory multiple myeloma. Dispenzieri A et al. Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.120. [Epub ahead of print]. Moving beyond maximum tolerated dose for targeted oncology drugs: Use of clinical utility index to optimize venetoclax…
DetailsThe Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma. Mishima Y et al. Cell Rep. 2017 Apr 4;19(1):218-224. doi: 10.1016/j.celrep.2017.03.025. Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma. Dupéré-Richer D et al. Curr Opin Hematol. 2017 Apr 22. doi: 10.1097/MOH.0000000000000358. [Epub ahead of print]. Epigenetic repression of miR-375 is the dominant mechanism for constitutive activation of the PDPK1/RPS6KA3 signalling axis in multiple…
DetailsDaratumumab for the treatment of multiple myeloma. Touzeau C et al. Expert Opin Biol Ther. 2017 Apr 24. doi: 10.1080/14712598.2017.1322578. [Epub ahead of print]. New developments in the treatment of multiple myeloma – clinical utility of daratumumab. McEllistrim C et al. Biologics. 2017 Apr 11;11:31-43. doi: 10.2147/BTT.S97633. eCollection 2017. Immunologic approaches for the treatment of multiple myeloma. Rasche L et al. Cancer Treat Rev. 2017 Apr 6;55:190-199. doi: 10.1016/j.ctrv.2017.03.010. [Epub ahead of print]. Which…
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